Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe
| Autor: | Alexandru Martiniuc, Monica Lacatus, Stefan Tudor, Mihnea Ionescu, Catalin Vasilescu, Traian Dumitrascu, Vlad Herlea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Multivariate analysis Complications Survival 030230 surgery Anastomosis 03 medical and health sciences 0302 clinical medicine medicine Radical gastrectomy business.industry Incidence (epidemiology) Gastroenterology medicine.disease Confidence interval Surgery Eastern european Oncology Pancreatic fistula 030220 oncology & carcinogenesis Relative risk Original Article business Gastric cancer |
| Zdroj: | Journal of Gastric Cancer |
| ISSN: | 2093-5641 2093-582X |
| Popis: | Purpose Incidence, risk factors, and clinical consequences of pancreatic fistula (POPF) after D1+/D2 radical gastrectomy have not been well investigated in Western patients, particularly those from Eastern Europe. Materials and Methods A total of 358 D1+/D2 radical gastrectomies were performed by surgeons with high caseloads in a single surgical center from 2002 to 2017. A retrospective analysis of data that were prospectively gathered in an electronic database was performed. POPF was defined and graded according to the International Study Group for Pancreatic Surgery (ISGPS) criteria. Uni- and multivariate analyses were performed to identify potential predictors of POPF. Additionally, the impact of POPF on early complications and long-term outcomes were investigated. Results POPF was observed in 20 patients (5.6%), according to the updated ISGPS grading system. Cardiovascular comorbidities emerged as the single independent predictor of POPF formation (risk ratio, 3.051; 95% confidence interval, 1.161-8.019; P=0.024). POPF occurrence was associated with statistically significant increased rates of postoperative hemorrhage requiring re-laparotomy (P=0.029), anastomotic leak (P=0.002), 90-day mortality (P=0.036), and prolonged hospital stay (P |
| Databáze: | OpenAIRE |
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