| Autor: |
Rodrigo M. Forti, Lucas J. Hobson, Emilie J. Benson, Tiffany S. Ko, Nicolina R. Ranieri, Gerard Laurent, M. Katie Weeks, Nicholas J. Widmann, Sarah Morton, Anthony M. Davis, Takayuki Sueishi, Yuxi Lin, Karli S. Wulwick, Nicholas Fagan, Samuel S. Shin, Shih-Han Kao, Daniel J. Licht, Brian R. White, Todd J. Kilbaugh, Arjun G. Yodh, Wesley B. Baker |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Biomed Opt Express |
| ISSN: |
2156-7085 |
| DOI: |
10.1364/boe.486363 |
| Popis: |
In this study, we used diffuse optics to address the need for non-invasive, continuous monitoring of cerebral physiology following traumatic brain injury (TBI). We combined frequency-domain and broadband diffuse optical spectroscopy with diffuse correlation spectroscopy to monitor cerebral oxygen metabolism, cerebral blood volume, and cerebral water content in an established adult swine-model of impact TBI. Cerebral physiology was monitored before and after TBI (up to 14 days post injury). Overall, our results suggest that non-invasive optical monitoring can assess cerebral physiologic impairments post-TBI, including an initial reduction in oxygen metabolism, development of cerebral hemorrhage/hematoma, and brain swelling. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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