Markers of cognitive reserve and dementia incidence in the English Longitudinal Study of Ageing
| Autor: | Pamela Almeida-Meza, Andrew Steptoe, Dorina Cadar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
Population ageing Longitudinal study Population Lower risk Article 03 medical and health sciences 0302 clinical medicine Cognitive Reserve Humans Medicine Dementia Longitudinal Studies 030212 general & internal medicine education Aged Cognitive reserve Aged 80 and over education.field_of_study business.industry Incidence Incidence (epidemiology) Hazard ratio Middle Aged medicine.disease Psychiatry and Mental health business 030217 neurology & neurosurgery Demography |
| Zdroj: | Br J Psychiatry |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.2020.54 |
| Popis: | BackgroundIn the current climate of an ageing population, it is imperative to identify preventive measures for dementia.AimsWe implemented a multifaceted index of cognitive reserve markers and investigated dementia incidence over 15 years of follow-up in a representative sample of the English population.MethodData were 12 280 participants aged ≥50 years from the English Longitudinal Study of Ageing, free from dementia at their baseline assessments during wave 1 (2002–2003), 3 (2006–2007) or 4 (2008–2009), and followed up until wave 8 (2016–2017). The Cognitive Reserve Index was constructed as a composite measure of education, occupation and leisure activities, using a standardised questionnaire. Cox proportional hazards regression models were used to estimate the hazard ratios of dementia in relation to cognitive reserve levels (low, medium and high) and its components (education, occupation and leisure activities).ResultsDuring the follow-up period, 602 participants aged 56–99 years developed dementia. Higher levels of cognitive reserve (hazard ratio 0.65, 95% CI 0.48–0.89, P = 0.008) were associated with a lower risk of dementia. An individual analysis of its components showed that higher levels of education (hazard ratio 0.56, 95% CI 0.36–0.88, P = 0.012), occupation (hazard ratio 0.72, 95% CI 0.56–0.91, P = 0.008) and leisure activities (hazard ratio 0.74, 95% CI 0.56–0.99, P = 0.047) were predictive of a reduced dementia risk, with the first two components particularly protective in younger participants (ConclusionsThis study showed a reduced risk of dementia for individuals with a higher level of cognitive reserve, represented by higher education, complex occupations and multifaceted level of leisure activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|