Cocaine decreases urinary prostacyclin release in pregnancy: correlation with uterine and umbilical Doppler velocimetry
| Autor: | D. S. Mastrogiannis, W. F. O'Brien, A. Luckenbau |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Thromboxane Pregnancy Trimester Third Urinary system Metabolite Urology Prostacyclin Umbilical Arteries Cocaine-Related Disorders chemistry.chemical_compound Pregnancy Laser-Doppler Flowmetry medicine Humans Rupture of membranes Prospective Studies business.industry Uterus Obstetrics and Gynecology Arteries Laser Doppler velocimetry medicine.disease Epoprostenol Pregnancy Complications chemistry Regional Blood Flow Case-Control Studies Pregnancy Trimester Second Pulsatile Flow Anesthesia Pediatrics Perinatology and Child Health Gestation Female business medicine.drug |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 14:383-388 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767050412331312220 |
| Popis: | The purpose of this study was to determine maternal urinary prostacyclin and thromboxane excretion in patients with recent cocaine use, compared to cocaine-free controls, and correlate the findings with Doppler velocimetry.Seventeen patients admitted with premature rupture of membranes between the gestational ages of 24 and 34 weeks were tested for urinary cocaine metabolites. Eleven patients had positive screening and six patients were negative and served as controls. After initial stabilization, 24-h urine collections were obtained and were assayed for the prostacyclin metabolite 2,3-dinor-6-keto-PGF(1alpha), and the thromboxane metabolite 2,3-dinor TXB2. These patients underwent uterine and umbilical arterial Doppler velocimetry expressed as the pulsatility index. Statistical analysis was performed by the SPSS statistical package using the non-paired Student t test, and Spearman correlation coefficient with p0.05 being considered significant.Compared with controls, urinary excretion of prostacyclin in pregnant women with recent cocaine use was significantly lower. The pulsatility index of the uterine arteries of the cocaine-positive individuals was higher than in controls and had a significant inverse correlation with prostacyclin metabolite excretion. Umbilical arterial velocimetry was similar in the two groups.Recent cocaine ingestion in pregnant women decreases production of prostacyclin and negatively affects the pulsatility index of the uterine artery. |
| Databáze: | OpenAIRE |
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