Which clinical and sonographic parameters may be useful to discriminate NASH from steatosis?
| Autor: | Enrico Maria Zardi, Beniamino Sadun, Giorgia Ghittoni, Bruno Palmentieri, Marcello Persico, Ilario de Sio, Paola Roselli, Eugenio Caturelli |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Nonalcoholic steatohepatitis
Adult Male medicine.medical_specialty Pathology Biopsy digestive system Gastroenterology Diagnosis Differential Internal medicine Histological diagnosis Diagnosis medicine Adult Biopsy Diagnosis Differential Fatty Liver diagnosis/pathology/ultrasonography Female Humans Liver pathology/ultrasonography Male Middle Aged Organ Size Retrospective Studies Spleen metabolism Humans Retrospective Studies Ultrasonography medicine.diagnostic_test business.industry Fatty liver diagnosis/pathology/ultrasonography nutritional and metabolic diseases Retrospective cohort study Organ Size Middle Aged medicine.disease pathology/ultrasonography digestive system diseases humanities body regions Natural history Fatty Liver Liver Liver biopsy Differential Female Steatosis business Spleen |
| Zdroj: | Journal of clinical gastroenterology. 45(1) |
| ISSN: | 1539-2031 |
| Popis: | The natural history of nonalcoholic steatohepatitis (NASH) includes the passage through steatosis.To retrospectively evaluate the usefulness of sonographic parameters compared to histological diagnosis when differentiating steatosis from NASH.This retrospective study reviewed records of patients with steatosis from databases of our Departments, selecting only those who had been diagnosed by sonography and liver biopsy [64 males (63.82%); 30 females (36.18%)].Attenuation of the echo amplitude (P0.05; odds ratio (OR): 3.43; confidence interval (CI): 1.02-11.57), focal fat sparing (P0.05; OR: 3; CI: 1.02-11.88) and splenic diameter (P0.05; OR: 1.66; CI: 1.04-3.26) were independent predictors of NASH. A significantly higher association of attenuation of the echo amplitude, enlarged splenic diameter, and presence of focal fat sparing was observed in NASH patients (P0.01).It is very difficult to build a predictive system to distinguish NASH from steatosis based on sonographic scores. However, it is already possible to differentiate NASH from steatosis by combining 3 simple sonographic parameters: attenuation of the echo amplitude, enlarged splenic diameter, and presence of focal fat sparing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|