Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat
| Autor: | S J Saunders, L O Frith, P Mason, W T Franks, J A Franks, J J Franks, R E Kirsch, Langley R. Purves |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Serum albumin
Fibrinogen Fibrin Fibrinogen Degradation Products Albumins medicine Animals Amino Acids Serum Albumin chemistry.chemical_classification Haptoglobins biology Haptoglobin Albumin General Medicine Peptide Fragments Rats Amino acid Secretory protein chemistry Biochemistry biology.protein Electrophoresis Polyacrylamide Gel Research Article medicine.drug |
| Zdroj: | Journal of Clinical Investigation. 67:575-580 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci110069 |
| Popis: | Previous studies are in conflict over the effect of infusing mixed fibrinogen-fibrin degradation products on fibrinogen synthesis, as determined by changes in fibrinogen concentration or by incorporation of labeled amino acids into fibrinogen. We have injected purified homologous fragments D1 and E into rats and measured their fibrinogen and albumin synthetic rates by the [14C]carbonate technique, a method that provides quantitative estimates of hepatic secretory protein synthesis. Fibrinogen fractional synthetic rates were increased 2.5 times in animals injected with fragment D1, compared with saline-injected controls. No increase were observed in fragment E-injected animals. Neither fragment produced changes in albumin synthesis. Fragment D increased plasma fibrinogen concentration, but did not raise plasma haptoglobin levels. These results suggest that fragment D is a regulator of fibrinogen synthesis. |
| Databáze: | OpenAIRE |
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