Case report: first symptomatic Candidatus Neoehrlichia mikurensis infection in Slovenia
| Autor: | Vesna Cvitković Špik, Tanja Selič-Kurinčič, Tatjana Avšič-Županc, Miha Simoniti, Mitja Lenart, Katja Strašek-Smrdel |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Candidatus Neoehrlichia mikurensis Slovenia 030106 microbiology Case Report Infectious and parasitic diseases RC109-216 Communicable Diseases Emerging Polymerase Chain Reaction 03 medical and health sciences Ticks Medical microbiology RNA Ribosomal 16S Prevalence medicine Animals Humans Fever of unknown origin Immunocompromised Pathogen Aged Doxycycline High prevalence Ixodes business.industry medicine.disease Anti-Bacterial Agents Anaplasmataceae Treatment Outcome 030104 developmental biology Infectious Diseases Parasitology Tick-Borne Diseases Anaplasmataceae Infections Emerging infectious disease Female Infection 16S rRNA PCR business Tick medicine.drug |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-4 (2021) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-021-06297-z |
| Popis: | Background Candidatus Neoehrlichia mikurensis (CNM) is an emerging tick-born pathogen and usually causes symptomatic infection only in immunocompromised patients. Apart from one described case found in the literature where cultivation was successful, all cases so far were diagnosed by using broad-range 16S rDNA PCR. Case presentation Our patient presented with a prolonged febrile state of unknown origin. Clinical presentation, extensive medical workup and classic microbiologic testing were non-conclusive. Several infectious agents and other causes for the febrile state were excluded. In the end, a broad-range 16S rDNA PCR was to be performed to confirm the diagnosis of CNM infection. Treatment was successful with doxycycline. Conclusions Due to the obscurity of the pathogen, diagnostic workup in CNM is prolonged and challenging. More awareness is need about this emerging infectious disease in countries with high prevalence of tick-borne diseases as standard microbiological methods are not successful in confirming the diagnosis. |
| Databáze: | OpenAIRE |
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