Klirens lidokaina kao farmakokinetički parametar metaboličke aktivnosti kod pacijenata sa oštećenjem jetre

Autor:	Marija Jovanović, Milena Kovačević, Sandra Vezmar-Kovačević, Ivan Palibrk, Jasna Bjelanović, Branislava Miljković, Katarina Vučićević
Jazyk:	srbština
Rok vydání:	2023
Předmět:	Biochemistry (medical) Clinical Biochemistry liver failure lidocaine insuficijencija jetre farmakokinetika pharmacokinetics
Zdroj:	Journal of Medical Biochemistry Journal of Medical Biochemistry (2023) 42(2):304-310
ISSN:	1452-8258
Popis:	Background: The study aimed to estimate lidocaine (LID) pharmacokinetic parameter values in patients with impaired liver function, level of correlation between the pharmacokinetic parameters and Child-Pugh class and change in pharmacokinetic parameters after liver tumor resection compared to the preoperative value. Methods: Patients with impaired liver function were subject to the LID test 1 day prior to, 3 and 7 days after the inter- vention. LID was administered in single i.v. dose of 1 mg/kg. Blood samples were collected at 15, 30 and 90 minutes after drug administration. Non-compartmental analysis was applied for calculating the pharmacokinetic parameters. Results: The study included 17 patients with the diagnosis of cirrhosis and 41 patients with liver tumor. In both groups of patients, the values of the coefficients of correlation show the best correlation between clearance (CL) and Child-Pugh score (-0.693, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b24d6df39e71a31f7837d5d9c4da63 http://farfar.pharmacy.bg.ac.rs/bitstream/id/12765/Lidocaine_Clearance_as_pub_2023.pdf Zobrazit plný text záznamu