Translational control in brain pathologies: biological significance and therapeutic opportunities

Autor: Poul H. Sorensen, Asad Jan, Alberto Delaidelli, Jochen Herms
Rok vydání: 2018
Předmět:
0301 basic medicine
mRNA translation
pathology [Brain Neoplasms]
Central nervous system
RNA-binding protein
RNA-binding proteins
metabolism [Neurodegenerative Diseases]
Biology
metabolism [RNA-Binding Proteins]
metabolism [RNA
Messenger]
Brain tumors
Pathology and Forensic Medicine
genetics [RNA
Messenger]
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
pathology [Brain]
medicine
Protein biosynthesis
MRNA transport
Humans
genetics [RNA-Binding Proteins]
ddc:610
RNA
Messenger
Control (linguistics)
Translation control
Messenger RNA
Brain Neoplasms
Neurodegenerative diseases
pathology [Neurodegenerative Diseases]
neurodegeneration
eEF2 kinase
Brain
RNA-Binding Proteins
Translation (biology)
Neurodegenerative Diseases
eEF2K
metabolism [Brain Neoplasms]
genetics [Brain Neoplasms]
030104 developmental biology
medicine.anatomical_structure
metabolism [Brain]
genetics [Neurodegenerative Diseases]
Protein Biosynthesis
Neurology (clinical)
Neuroscience
Nucleus
030217 neurology & neurosurgery
Zdroj: Delaidelli, A, Jan, A, Herms, J & Sorensen, P H 2019, ' Translational control in brain pathologies : biological significance and therapeutic opportunities ', Acta Neuropathologica, vol. 137, no. 4, pp. 535-555 . https://doi.org/10.1007/s00401-019-01971-8
Delaidelli, A, Asad, J, Herms, J & Sorensen, P H 2019, ' Translational control in brain pathologies : biological significance and therapeutic opportunities ', Acta Neuropathologica . https://doi.org/10.1007/s00401-019-01971-8
Acta neuropathologica 137(4), 535-555 (2019). doi:10.1007/s00401-019-01971-8
ISSN: 1432-0533
DOI: 10.1007/s00401-019-01971-8
Popis: Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.
Databáze: OpenAIRE
Externí odkaz: