Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy
| Autor: | Petrucciani, Niccolò, Carra, Maria Clotilde, Martínez-Pérez, Aleix, Vitali, Giulio Cesare, Landi, Filippo, Genova, Pietro, Memeo, Riccardo, Brunetti, Francesco, Espin, Eloy, Ris, Frédéric, De'angelis, Nicola, EUMARCS Study Group |
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| Přispěvatelé: | NICCOLÒ PETRUCCIANI, MARIA CLOTILDE CARRA, ALEIX MARTÍNEZ-PÉREZ, GIULIO CESARE VITALI, FILIPPO LANDI, PIETRO GENOVA, RICCARDO MEMEO, FRANCESCO BRUNETTI, ELOY ESPIN, FREDERIC RIS, NICOLA DE'ANGELIS |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Multivariate analysis Colorectal cancer Disease-free survival medicine.medical_treatment LODDS Locally advanced Adenocarcinoma Disease-Free Survival Log odds of positive lymph node Rectal Adenocarcinoma Medicine Humans Rectal cancer Log odds of positive lymph nodes Neoadjuvant therapy Aged Neoplasm Staging Aged 80 and over Receiver operating characteristic ddc:617 business.industry Rectal Neoplasms Hazard ratio General Medicine Nodal ratio Chemoradiotherapy Middle Aged medicine.disease Prognosis Confidence interval Neoadjuvant Therapy Oncology disease-free survival lodds log odds of positive lymph nodes neoadjuvant therapy nodal ratio rectal cancer adenocarcinoma adult aged aged 80 and over female humans lymph nodes male middle aged neoplasm recurrence Local Female Radiology Lymph Nodes Neoplasm Recurrence Local business |
| Zdroj: | Anticancer Research, Vol. 39, No 4 (2019) pp. 2113-2120 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis. Results: At multivariate analysis, ypN, nodal ratio, and LODDS were all significantly associated with disease-free survival, but LODDS showed the strongest association (hazard ratio(HR)=2.39; 95% confidence interval(CI)=1.05-5.48; p=0.039). Conclusion: LODDS appears to be a useful prognostic indicator in the prediction of disease-free survival of patients undergoing neoadjuvant chemoradiotherapy and proctectomy for locally advanced rectal cancer. |
| Databáze: | OpenAIRE |
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