The effects of sildenafil citrate on feto-placental development and haemodynamics in a rabbit model of intrauterine growth restriction
| Autor: | Maria Arias-Alvarez, Rosa M. Garcia-Garcia, Pedro Lorenzo, Susana Astiz, Pilar García Rebollar, Jorge Lopez-Tello, Maria-Ángeles Jiménez-Martínez, Maria Martin Rodriguez, Antonio Gonzalez-Bulnes, Laura Torres-Rovira, Alicia Barbero-Fernández |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biología Vasodilator Agents Placenta Hemodynamics Intrauterine growth restriction Reproductive technology Muscle hypertrophy Fetal Development Random Allocation 0302 clinical medicine Endocrinology Pregnancy Silvicultura reproductive and urinary physiology 2. Zero hunger 030219 obstetrics & reproductive medicine Fetal Growth Retardation 3. Good health medicine.anatomical_structure Cerebrovascular Circulation Pulsatile Flow embryonic structures Middle cerebral artery Female Rabbits Biotechnology medicine.medical_specialty Placental insufficiency Biology Sildenafil Citrate 03 medical and health sciences Fetus medicine.artery Internal medicine Genetics medicine Decidua Animals Placental Circulation Molecular Biology Crosses Genetic Caloric Restriction Maternal Nutritional Physiological Phenomena Phosphodiesterase 5 Inhibitors medicine.disease Placentation Disease Models Animal 030104 developmental biology Reproductive Medicine Animal Science and Zoology Vascular Resistance Developmental Biology |
| Zdroj: | Repositorio de Resultados de Investigación del INIA INIA: Repositorio de Resultados de Investigación del INIA Reproduction, Fertility, And Development, ISSN 1031-3613, 2017-05, Vol. 29, No. 6 Archivo Digital UPM Universidad Politécnica de Madrid Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA |
| Popis: | The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model of intrauterine growth restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted to 50% of dietary requirements (Group R) or restricted and treated with SC (Group SC). The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto–placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA. Furthermore, fetuses in the SC group had significantly higher biparietal and thoracic diameters and longer crown–rump lengths than fetuses in Group R. Hence, the SC group had a reduced IUGR rate and a higher kit size at birth compared with Group R. In conclusion, SC may provide potential benefits in pregnancies with placental insufficiency and IUGR, partially counteracting the negative effects of food restriction on placental development and fetal growth. However, the present study also found evidence of a possible blood overflow in the brain that warrants further investigation. |
| Databáze: | OpenAIRE |
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