The role of stress-regulation genes in moderating the association of stress and daily-life psychotic experiences

Autor: Manel Monsonet, Paula Cristóbal-Narváez, Anna Racioppi, Araceli Rosa, Thomas R. Kwapil, Lídia Hinojosa-Marqués, Neus Barrantes-Vidal, R. van Winkel, Tamara Sheinbaum, Inez Myin-Germeys, M. de Castro-Catala, Tecelli Domínguez-Martínez
Rok vydání: 2017
Předmět:
Adult
Male
Psychosis
Ecological Momentary Assessment
Individuality
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Childhood trauma
Tacrolimus Binding Proteins
Young Adult
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Longitudinal Studies
psychosis
Allele
gene–environment interaction
childhood trauma
experience sampling method
Stressor
Haplotype
Original Articles
medicine.disease
Oxytocin receptor
Gene-environment interaction
Experience sampling method
Daily-life stressors
030227 psychiatry
Psychiatry and Mental health
Cross-Sectional Studies
Adult Survivors of Child Adverse Events
Psychotic Disorders
Female
Gene-Environment Interaction
Original Article
daily‐life stressors
FKBP5
Psychology
Psychosocial
RGS Proteins
Stress
Psychological
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Acta Psychiatrica Scandinavica
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 0001-690X
DOI: 10.1111/acps.12789
Popis: Objective The interaction of single nucleotide polymorphisms with both distal and proximal environmental factors across the extended psychosis phenotype is understudied. This study examined (i) the interaction of relevant SNPs with both early‐life adversity and proximal (momentary) stress on psychotic experiences (PEs) in an extended psychosis sample; and (ii) differences between early‐psychosis and non‐clinical groups for these interactions. Methods Two hundred and forty‐two non‐clinical and 96 early‐psychosis participants were prompted randomly eight times daily for 1 week to complete assessments of current experiences, including PEs and stress. Participants also reported on childhood trauma and were genotyped for 10 SNPs on COMT, RGS4, BDNF, FKBP5, and OXTR genes. Results Unlike genetic variants, distal and proximal stressors were associated with PEs in both samples and were more strongly associated with PEs in the early‐psychosis than in the non‐clinical group. The RGS4 TA and FKBP5 CATT haplotypes interacted with distal stress, whereas the A allele of OXTR (rs2254298) interacted with proximal stress, increasing momentary levels of PEs in the early‐psychosis group. No interactions emerged with COMT or BDNF variants. Conclusion Individual differences in relevant stress‐regulation systems interact with both distal and proximal psychosocial stressors in shaping the daily‐life manifestation of PEs across the psychosis continuum.
Databáze: OpenAIRE
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