Genotoxic and mutagenic effects of chlorothalonil on the estuarine fish Micropogonias furnieri (Desmarest, 1823)
| Autor: | Marianna Basso Jorge, Thamires Alexsandra Torres, Larissa Cristine Carvalho Penha, Luis Fernando Carvalho-Costa, Muryllo Santos Castro, Gilberto Fillmann, Ricardo Luvizotto-Santos |
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| Rok vydání: | 2021 |
| Předmět: |
Micronucleus Tests
Chlorothalonil DNA damage Health Toxicology and Mutagenesis Aquatic ecosystem Zoology General Medicine Biology Pollution Perciformes Comet assay Fungicide chemistry.chemical_compound chemistry Nitriles Micronucleus test Animals Environmental Chemistry Ecotoxicology Comet Assay Ecotoxicity Ecosystem DNA Damage Mutagens |
| Zdroj: | Environmental Science and Pollution Research. 29:23504-23511 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-021-17328-2 |
| Popis: | Chlorothalonil is a fungicide widely used in agriculture as well as an active ingredient in antifouling paints. Although it causes toxic effects on non-target organisms and can accumulate in fish tissues, little is known about its sublethal effects. Thus, genotoxic and mutagenic effects of intraperitoneal injected chlorothalonil in Micropogonias furnieri, an estuarine fish of frequent human consumption and a promising test-organism for ecotoxicological assays, were assessed. Chlorothalonil showed to be genotoxic (DNA damage by comet assay) and mutagenic (micronuclei, nuclear buds, apoptotic fragments, and bilobed cells) even at the lowest dose tested (0.35 μg g−1) and in a dose-dependent manner (0.35 and 3.5 μg g−1) for micronuclei, apoptotic fragments, and bilobed cells. As genomic instability may lead to carcinogenesis, the present evidence can assist decision-makers in banning this compound since any benefit toward food production is outweighed by the hazard to aquatic ecosystems and human health. |
| Databáze: | OpenAIRE |
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