Enantiomeric Ratio of Amino Acids as a Tool for Determination of Aging and Disease Diagnostics by Chromatographic Measurement
| Autor: | Eva Tesařová, Květa Kalíková, Tereza Šlechtová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Chromatographic measurement
Filtration and Separation 01 natural sciences Analytical Chemistry lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Derivatization chemistry.chemical_classification amino acids Chromatography 010401 analytical chemistry aging biomarkers Highly selective lcsh:QC1-999 0104 chemical sciences Amino acid chemistry Biochemistry lcsh:QD1-999 Separation method chromatography enantiomeric ratio Enantiomer 030217 neurology & neurosurgery lcsh:Physics |
| Zdroj: | Separations, Vol 3, Iss 4, p 30 (2016) |
| ISSN: | 2297-8739 |
| Popis: | Occurrence of d-amino acids in living organisms is a useful indicator of various changes, diseases, or disorders. Determination of amino acid enantiomers, namely the enantiomeric ratio of amino acids or excess of certain d-amino acids, represents a useful tool in the studies of aging processes or biomarkers in disease/disorder diagnosis in humans. The amount of d-amino acids is usually very low. Therefore, suitable sample pretreatment, often derivatization, and highly selective and sensitive separation methods are essential for d-amino acid analysis in this field. Chromatographic techniques offer appropriate choices for solving these tasks. This review covers the advances in methodology and development of improved instrumental chromatographic methods focused on d,l-amino acid separation and determination. New findings in the area of possible d-amino acid biomarkers are also included. |
| Databáze: | OpenAIRE |
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