Oral administration of methylergometrine shows a late and unpredictable effect on the non-pregnant human menstruating uterus

Autor: Tom B. Vree, A.N.J.A. de Groot, P.W.J. van Dongen, Tom K.A.B. Eskes
Jazyk: angličtina
Rok vydání: 1995
Předmět:
Technology
Economics
Uterus
Administration
Oral
Physiology
Pharmacy
Acid-Base Imbalance
Fetal Distress
Biopharmaceutics
Menstruation
Uterine Contraction
Analysis of Collective Decision-Making
Oral administration
Reproduction Techniques
Reproductive Control Agents (Non MeSH)
Fetal Monitoring
GeneralLiterature_REFERENCE(e.g.
dictionaries
encyclopedias
glossaries)
Methylergometrine
Brain Diseases
Education
Medical
Reproduction
Late effect
Obstetrics and Gynecology
Brain
Fetal Diseases
medicine.anatomical_structure
Female Genital Diseases and Pregnancy Complications (Non MeSH)
Injections
Intravenous
Pharmacology
Clinical
Female
medicine.symptom
Half-Life
medicine.drug
Adult
medicine.medical_specialty
Research on anesthesia
pain and control of these
Cmax
Fertilization in Vitro
Education
Fertility Agents
Clinical
Fetus
Methylergonovine
Pharmacokinetics
Drug Therapy
Internal medicine
Medical
Evaluation Studies
Pressure
medicine
Humans
Technology
Pharmaceutical
Economics
Pharmaceutical
Pharmacology
business.industry
Pharmacoepidemiology
Estrogens
Fertility Agents
Female
Outcome and Process Assessment (Health Care)
Bioavailability
Culture Media
Pregnancy Complications
Kinetics
Endocrinology
Overig onderzoek betreffende anesthesie
pijn en de sturing daarvan
Reproductive Medicine
Infertility
Pharmaceutical
business
Sleep
Estimation
Gonadotropins
Zdroj: European Journal of Obstetrics & Gynecology and Reproductive Biology, 60, 101-107
European Journal of Obstetrics & Gynecology and Reproductive Biology, 60, pp. 101-107
European Journal of Obstetrics & Gynecology and Reproductive Biology, 60, 2, pp. 101-107
ISSN: 0301-2115
Popis: Objective: To study the pharmacodynamic and pharmacokinetic properties of oral and intravenous methylergometrine upon uterine motility during menstruation. Study-design: Intra-uterine pressure was measured in six volunteers with a fluid-filled sponge-tipped catheter during menstruation. Methylergometrine was given orally (0.5 mg) or intravenously (0.2 mg) in a cross-over design. Results: After intravenous administration, a fast increase of the frequency of uterine contractions and basal tone occurred with a decrease of amplitude, lasting at least 30 min. Oral administration had a late and less marked effect on uterine motility. An intravenous dose administered 24 h after an oral dose had no effect on uterine motility. Pharmacokinetic data, such as the maximum plasma concentration (Cmax), the time at which Cmax is reached (tmax) and the half-life of absorption ( t 1 2abs ) also demonstrated large individual variations after oral administration. Conclusion: Oral administration of methylergometrine had an unpredictable and late effect on uterine motility on the menstruating uterus, probably due to an unpredictable bioavailability, in contrast with the fast and predictable effect after intravenous administration.
Databáze: OpenAIRE
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