Supplementary Figure 3 from The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib

Autor: Yves Pommier, Kathleen Kelly, Junko Murai, Moudjib Etemadi, Michael L. Beshiri, Shyam K. Sharan, Zoe Weaver Ohler, Melanie Gordon, Ludmila Szabova, Laetitia Marzi
Rok vydání: 2023
DOI: 10.1158/1078-0432.22471658
Popis: LMP776 is synergistic with talazoparib in BRCA1-/- cells. Cell viability curves of talazoparib in DT40 WT (blue symbols and curves) and BRCA1-/- cells (red) with the indicated concentrations of LMP776. Open symbols and dashed lines correspond to talazoparib alone.
Databáze: OpenAIRE