Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
| Autor: | Guillaume Savoye, Rachel Marion-Letellier, Linda Yaker, Charlène Guérin, Alexis Goichon, Matthieu Rouland, Asma Amamou, Moutaz Aziz |
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| Přispěvatelé: | Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), CHU Rouen, Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, douville, sabine, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Exacerbation Science Inflammation Context (language use) Intestinal fibrosis Article Extracellular matrix 03 medical and health sciences 0302 clinical medicine Medicine Animals Humans Intestinal Mucosa Fibroblast Myofibroblasts Gastrointestinal diseases 2. Zero hunger Extracellular Matrix Proteins Multidisciplinary business.industry Fibroblasts Colitis Inflammatory Bowel Diseases Fibrosis 3. Good health Diet Rats Intestines [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Disease Models Animal 030104 developmental biology medicine.anatomical_structure Trinitrobenzenesulfonic Acid Preclinical research Immunology 030211 gastroenterology & hepatology Salts medicine.symptom business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Myofibroblast Dietary salt |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-94280-8⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-94280-8⟩ |
| ISSN: | 2045-2322 |
| Popis: | Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular matrix (ECM) proteins secreted by myofibroblasts. Factors promoting intestinal fibrosis are unknown, but diet appears to be a critical component in its development. Consumption of salt above nutritional recommendations can exacerbate chronic inflammation. So far, high salt diet (HSD) have not been thoroughly investigated in the context of intestinal fibrosis associated to IBD. In the present study, we analyze the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, or in human colon fibroblast cells. Here, we have shown that high-salt diet exacerbates undernutrition and promoted ECM-associated proteins in fibroblasts. Taken together, our results suggested that dietary salt can activate intestinal fibroblasts, thereby contributing to exacerbation of intestinal fibrosis. Dietary salt may be considered as a putative environmental factor that drives intestinal fibrosis risk. |
| Databáze: | OpenAIRE |
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