Identification of two distinct subsets of bovine γδ T cells with unique cell surface phenotype and tissue distribution
| Autor: | William C. Davis, Niall D. MacHugh, C R Wyatt, M.J. Carol, José A. Orden, J.K. Mburu |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.drug_class
T cell Immunology Population Thymus Gland Biology Transfection Monoclonal antibody Immunophenotyping Immunoenzyme Techniques Antigen T-Lymphocyte Subsets medicine Animals Immunology and Allergy education education.field_of_study T-cell receptor Receptors Antigen T-Cell gamma-delta Flow Cytometry Phenotype Molecular biology medicine.anatomical_structure Antigens Surface Cattle Lymph Nodes Spleen CD8 Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2567 0019-2805 |
| DOI: | 10.1046/j.1365-2567.1997.00350.x |
| Popis: | We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215,000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2, CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition, this subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution. |
| Databáze: | OpenAIRE |
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