Rapid Eye Movement Sleep Deprivation Contributes to Reduction of Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Rat
| Autor: | Ronald Szymusiak, Ruben Guzman-Marin, Robert Nienhuis, Dennis McGinty, Tariq Bashir, Natalia Suntsova |
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| Rok vydání: | 2008 |
| Předmět: |
Male
REM Sleep Deprivation and Neurogenesis Rapid eye movement sleep Sleep REM Hippocampal formation Hippocampus Non-rapid eye movement sleep Rats Sprague-Dawley Physiology (medical) medicine Animals Neuroscience of sleep Cell Proliferation Neurons Electromyography Stem Cells Dentate gyrus Neurogenesis Age Factors Electroencephalography Immunohistochemistry Dideoxynucleosides Rats Sleep deprivation Ki-67 Antigen Dentate Gyrus Nerve Degeneration Sleep Deprivation Neurology (clinical) medicine.symptom Sleep onset Corticosterone Psychology Neuroscience |
| Zdroj: | Sleep. 31:167-175 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/31.2.167 |
| Popis: | THE SUBGRANULAR CELL LAYER IN THE DENTATE GYRUS (DG) OF THE ADULT HIPPOCAMPUS CONTAINS PROGENITOR CELLS, WHICH HAVE THE POTENTIAL TO proliferate and differentiate into neurons. These progenitors mature locally into granule cells of the DG, sending axonal projections to area CA3 and dendrites into the molecular layer.1.2 Adult neurogenesis has been demonstrated in birds and several mammals, including humans. The processes of cell proliferation, migration, maturation, and survival are all subject to modulation by experiential events.3 Stress is an important negative regulator of cell proliferation.4,5 Previously we reported that 96 hours of total sleep deprivation (TSD) affects neurogenesis in the rat DG by reducing cell proliferation in the subgranular cell layer, and the percentage of new cells later expressing a neuronal marker.6,7 The inhibitory effects of extended sleep deprivation have been confirmed.8 However, mammalian sleep is physiologically heterogeneous. The two primary stages of mammalian sleep, non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, have very different, even opposite, electrophysiologic and metabolic properties, compared with waking, and could have different effects on neurogenesis. Revealing the relative impact of REM and NREM sleep on neurogenesis is a necessary step in understanding the mechanisms underlying suppression of neurogenesis in response to sleep loss. The aim of the present study was to assess the effect of REM sleep deprivation (REMD) on neurogenesis in the DG of the adult rat. To achieve REM deprivation, rats lived on a treadmill that was briefly activated when REM was detected by fast Fourier transform analysis of the electroencephalogram (EEG) and electromyogram (EMG) activity. Yoked control (YC) animals lived on the same treadmill and were subjected to the same treadmill movements. |
| Databáze: | OpenAIRE |
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