Risk of fragility fracture among patients with late-onset psoriasis: a UK population-based study
| Autor: | A. Abdul Sultan, Samantha L. Hider, Sara Muller, Milisa Blagojevic-Bucknall, Christian D Mallen, Zoe Paskins, Jon Packham, Edward Roddy, Rebecca Whittle, Toby Helliwell |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Risk Assessment Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis medicine Humans Aged 030203 arthritis & rheumatology Aged 80 and over business.industry Proportional hazards model Incidence Hazard ratio Arthritis Psoriatic Middle Aged medicine.disease Confidence interval Rheumatology United Kingdom Methotrexate Case-Control Studies Female Dermatologic Agents Medical Record Linkage Age of onset business Immunosuppressive Agents Osteoporotic Fractures Cohort study |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 29(7) |
| ISSN: | 1433-2965 |
| Popis: | This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to matched controls (hazard ratio (HR) = 1.10; 95% confidence interval (CI) 1.04, 1.16). This study aimed to examine fracture risk in patients with late-onset psoriasis and investigate the effect of methotrexate on fracture risk. A cohort study was conducted using primary care records from the UK-based Clinical Practice Research Datalink. Individuals aged 40 years and over, with incident (new onset) diagnoses of psoriasis, were identified from 1990 to 2004 and followed up until 2015. For each exposed individual, up to four age-, gender-, and practice-matched controls were randomly selected. Incidence rates of fragility fracture (hip, vertebral, spine, radius or unspecified site) per 10,000 person-years were calculated and hazard rates were compared to the unexposed using Cox regression models. The risk of fracture was also estimated, within the exposed group for patients receiving/not receiving methotrexate. Twenty-four thousand two hundred nineteen patients with psoriasis and 94,820 controls were identified. The absolute rate of fracture in psoriasis patients was 58 per 10,000 person-years (95% CI 55, 61) and 53 per 10,000 person-years in the matched controls (CI 52, 54). Psoriasis patients had a 10% increased risk of fracture compared to their matched controls (HR = 1.10; 95% CI 1.04, 1.16). Methotrexate use was not associated with increased risk (HR = 0.91; 95% CI 0.72, 1.15). Identifying additional clinical factors associated with increased fracture risk is important in improving fracture risk stratification. Further work is needed to determine the relationship between age of onset of psoriasis and fracture risk, explore causative explanations, and identify if existing fracture risk stratification tools underestimate fracture risk in patients with psoriasis. |
| Databáze: | OpenAIRE |
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