Immunogenicity of a peptide‐based anti‐IgE conjugate vaccine in non‐human primates
| Autor: | Heather L. Davis, Brian Robert Champion, Ghania Chikh, James D. Fraser, Lu Zhang, James R. Merson, Michael J. McCluskie, Jennifer Marie Thorn, Risini D. Weeratna |
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| Rok vydání: | 2016 |
| Předmět: |
Primates
0301 basic medicine Allergy Urticaria medicine.drug_class Immunology Omalizumab Pharmacology Antibodies Monoclonal Humanized Immunoglobulin E Monoclonal antibody 03 medical and health sciences 0302 clinical medicine Conjugate vaccine vaccine medicine Animals Humans Immunology and Allergy 030212 general & internal medicine Dosing Original Research Vaccines Conjugate biology business.industry Immunogenicity Antibodies Monoclonal medicine.disease Asthma anti‐IgE antibodies Antibodies Anti-Idiotypic IgE peptide conjugates 030104 developmental biology biology.protein IgE Antibody business medicine.drug |
| Zdroj: | Immunity, Inflammation and Disease |
| ISSN: | 2050-4527 |
| Popis: | The anti‐human immunoglobulin E (IgE) monoclonal antibody, omalizumab (Xolair®, Genentech, South San Fransisco, CA), is effective in the treatment of poorly controlled moderate to severe allergic asthma and chronic idiopathic urticaria. It acts by specifically binding to the constant domain (Cϵ3) of free human IgE in the blood and interstitial fluid. Although efficacious, use of omalizumab is limited due to restrictions on patient weight and pre‐existing IgE levels, and frequent dosing (q2–4 weeks). A vaccine inducing anti‐IgE antibodies has the potential for similar clinical benefits with less frequent dosing and relatively lower cost of goods. We developed a vaccine containing two IgE peptide‐conjugates targeting the Cϵ3 domain of human IgE. As part of preclinical evaluation of the vaccine to optimize formulation and dose prior to initiating clinical studies, we evaluated the vaccine in non‐human primates, and demonstrate the induction of anti‐peptide antibodies that can bind to conformationally intact human IgE and are capable, at least in some animals, of substantial lowering circulating IgE levels. |
| Databáze: | OpenAIRE |
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