The early effect of irradiation on ventilatory function in bronchial carcinoma
| Autor: | S. J. Cameron, J. G. Pearson, W. Lutz, I. W. B. Grant |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Male Thorax medicine.medical_specialty Adolescent Urology medicine Edema Humans Radiology Nuclear Medicine and imaging Irradiation Lobar Bronchus Cell damage Aged Early effect Treatment regimen business.industry Respiration Bronchial Neoplasms Carcinoma Ventilatory function General Medicine Middle Aged respiratory system medicine.disease respiratory tract diseases Surgery Radiation Effects Trachea Urinary Bladder Neoplasms Bronchial carcinoma Spirometry Carcinoma Squamous Cell Female Respiratory Insufficiency business |
| Zdroj: | Clinical Radiology. 20:12-18 |
| ISSN: | 0009-9260 |
| DOI: | 10.1016/s0009-9260(69)80047-4 |
| Popis: | The early effect of ionizing irradiation on ventilatory function has been studied in 14 patients with bronchial carcinoma compressing the trachea or both main bronchi. All these patients showed a significant fall in forced expiratory volume (FEV 1 ) during the first 3 days of treatment (after a dose of 500–1050 rads) followed by a steady improvement, which reached or exceeded the pretreatment figure by the end of 7 days. Of 28 patients with bronchial carcinoma situated in a main or lobar bronchus, 22 showed a significant reduction in FEV 1 during the first 4 days of irradiation (after a dose of 500–1400 rads). Eight patients with peripherally situated tumours and 8 patients with tumours outside the thorax receiving similar treatment regimens were studied as controls. Nine of these 16 patients showed a reduction in FEV 1 but this was significantly less marked in both numbers of patients and severity of decline than in the groups with major bronchial involvement. The results suggest that a significant reduction in FEV 1 occurs in many patients receiving irradiation and that this fall is greatest when a proximal tumour is treated. It is suggested that the early reduction in FEV 1 could be due to intra and extra cellular oedema with resultant tumour swelling due to cell damage and that this effect is opposed by a steadily increasing rate of tumour shrinkage due to cell death as the irradiation effect continues. Tumour shrinkage results in rapid improvement in ventilatory function. The findings are discussed in relation to the management of patients who have bronchial carcinoma causing critical airways obstruction. |
| Databáze: | OpenAIRE |
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