Randomized, multicenter study: on-demand versus continuous maintenance treatment with esomeprazole in patients with non-erosive gastroesophageal reflux disease
| Autor: | Ekkehard Bayerdörffer, Lars-Erik Svedberg, Luis Rodrigo, Fermín Mearin, Marc-Andre Bigard, Nanna Keeling, Tore Persson, Werner Weiss, Hennie Grundling, Juan Enrique Dominguez Muñoz, Stefan Eklund |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty On-demand Nerd Discontinuation Gastroesophageal reflux disease Gastroenterology Drug Administration Schedule Esomeprazole Maintenance Chemotherapy 03 medical and health sciences 0302 clinical medicine Maintenance therapy Heartburn Internal medicine medicine Humans Non-erosive reflux disease Reflux esophagitis Esophagitis Peptic business.industry Reflux Proton Pump Inhibitors General Medicine Middle Aged Confidence interval Treatment Outcome Patient Satisfaction 030220 oncology & carcinogenesis Gastroesophageal Reflux 030211 gastroenterology & hepatology Female medicine.symptom business medicine.drug Research Article |
| Zdroj: | BMC Gastroenterology |
| ISSN: | 1471-230X |
| Popis: | Most patients with gastroesophageal reflux disease experience symptomatic relapse after stopping acid-suppressive medication. The aim of this study was to compare willingness to continue treatment with esomeprazole on-demand versus continuous maintenance therapy for symptom control in patients with non-erosive reflux disease (NERD) after 6 months. This multicenter, open-label, randomized, parallel-group study enrolled adults with NERD who were heartburn-free after 4 weeks’ treatment with esomeprazole 20 mg daily. Patients received esomeprazole 20 mg daily continuously or on-demand for 6 months. The primary variable was discontinuation due to unsatisfactory treatment. On-demand treatment was considered non-inferior if the upper limit of the one-sided 95 % confidence interval (CI) for the difference between treatments was |
| Databáze: | OpenAIRE |
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