THE NMR CONFORMATION STUDY OF THE COMPLEXES OF DEOXYCYTIDINE KINASE (dCK) AND 2′-DEOXYCYTIDINE/2′-DEOXYADENOSINE

Autor:	Tatiana Maltseva, András Földesi, Jyoti Chattopadhayaya, Staffan Eriksson, Elena V. Usova, J Milecki
Rok vydání:	2001
Předmět:	Deoxyadenosines Protein Conformation Stereochemistry Chemistry 2'-deoxyadenosine General Medicine Deoxycytidine kinase Deoxycytidine Biochemistry chemistry.chemical_compound Deoxycytidine Kinase Genetics Humans Molecular Medicine Nuclear Magnetic Resonance Biomolecular
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 20:1225-1228
ISSN:	1532-2335 1525-7770
Popis:	The structures of the bound 13C/2H double-labelled 2'(R/S), 5'(R/S)-2H2-1',2',3',4',5'-13C5-2'-deoxyadenosine and the corresponding 2'-deoxycytidine moieties in the complexes with human deoxycytidine kinase (dCK) have been characterized for the first time by the solution NMR spectroscopy, using Transferred Dipole-Dipole Cross-correlated Relaxation and Transferred nOe experiments. It has been shown that the ligand adopts a South-type sugar conformation when bound to dCK.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a1485fa31882fedaadcdbb215780c5 https://doi.org/10.1081/ncn-100002523 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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