THE NMR CONFORMATION STUDY OF THE COMPLEXES OF DEOXYCYTIDINE KINASE (dCK) AND 2′-DEOXYCYTIDINE/2′-DEOXYADENOSINE
Autor: | Tatiana Maltseva, András Földesi, Jyoti Chattopadhayaya, Staffan Eriksson, Elena V. Usova, J Milecki |
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Rok vydání: | 2001 |
Předmět: | |
Zdroj: | Nucleosides, Nucleotides and Nucleic Acids. 20:1225-1228 |
ISSN: | 1532-2335 1525-7770 |
Popis: | The structures of the bound 13C/2H double-labelled 2'(R/S), 5'(R/S)-2H2-1',2',3',4',5'-13C5-2'-deoxyadenosine and the corresponding 2'-deoxycytidine moieties in the complexes with human deoxycytidine kinase (dCK) have been characterized for the first time by the solution NMR spectroscopy, using Transferred Dipole-Dipole Cross-correlated Relaxation and Transferred nOe experiments. It has been shown that the ligand adopts a South-type sugar conformation when bound to dCK. |
Databáze: | OpenAIRE |
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