Objective and subjective improvement in children with idiopathic detrusor overactivity after intravesical botulinum toxin injection: A preliminary report
| Autor: | Ghazi Mohammad Al Edwan, Rawand Al Adwan, Kameel M. Afram, Muheilan Mustafa Muheilan, Omar Ababneh, Mohammad M. Shaath, Deema Al Adwan, Omar Nabeeh M. Atta, Waleed S. Mahafza, Hammam Mansi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Urinary Bladder Urology Urinary incontinence Botulinum toxin injection 03 medical and health sciences 0302 clinical medicine Quality of life Refractory Enuresis 030225 pediatrics Surveys and Questionnaires medicine Humans Prospective Studies Botulinum Toxins Type A Child business.industry Urinary Bladder Overactive General Medicine medicine.disease Botulinum toxin Clinical trial Urodynamics Administration Intravesical Treatment Outcome Urinary Incontinence Overactive bladder Neuromuscular Agents 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Quality of Life Surgery Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of pediatric surgery. 54(3) |
| ISSN: | 1531-5037 |
| Popis: | Objective The purpose of this study is to evaluate the effect of Intravesical Botulinum toxin injection on the symptoms and urodynamic parameters in pediatric patients with idiopathic overactive bladder (iOAB) refractory to medical treatment. Materials and methods The study was designed as an open-label uncontrolled therapeutic clinical trial. The eligible patients who underwent Intravesical botulinum toxin injection were evaluated before treatment. The evaluation included a 7-day paper bladder diary to assess OAB symptoms (frequency, urgency urinary incontinence (UUI) and nocturnal enuresis (NE)), filling the Arabic International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI short form), and conducting urodynamic study. The Urodynamic parameters obtained were the maximum filling detrusor pressure, cystometric bladder capacity, and compliance. After 12 weeks of the intravesical injection, the patients were revaluated and the results were compared using paired samples t-test. Results The study enrolled 75 patients. And of those, statistical analysis was done on 46 patients who did follow the study protocols. The mean age was 8.9 years and male to female ratio was 1:4. There was a statistically significant improvement in overactive bladder symptoms and urodynamic parameters in the patient injected with botulinum toxin with minimal side effects. Conclusion The evidence in this study would support the safety and efficacy of Intravesical botulinum toxin injection in children with refractory idiopathic OAB with significant improvement of symptoms, quality of life, as well as urodynamic parameters. Type of Study Open-label uncontrolled therapeutic clinical trial. Level of Evidence III |
| Databáze: | OpenAIRE |
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