Progression of regional grey matter atrophy in multiple sclerosis
| Autor: | Massimo Filippi, Viktor Wottschel, Lukas Pirpamer, Jeroen J. G. Geurts, Alan J. Thompson, Hugo Vrenken, Christian Enzinger, Niamh Cawley, Daniel C. Alexander, Sebastien Ourselin, M. Laura Stromillo, Razvan V. Marinescu, Jaume Sastre-Garriga, Serena Ruggieri, M. Jorge Cardoso, Marco Battaglini, Ferran Prados, Arman Eshaghi, Floriana De Angelis, Claudio Gasperini, Carmen Tur, Olga Ciccarelli, Alex Rovira, Frederik Barkhof, Wallace Brownlee, Maria A. Rocca, Cyra E. Leurs, Bernard M. J. Uitdehaag, Declan T. Chard, Alexandra L. Young, Nicholas C. Firth, Claudia Am Gandini Wheeler-Kingshott, Nicola De Stefano |
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| Přispěvatelé: | Eshaghi, Arman, Marinescu, Razvan V., Young, Alexandra L., Firth, Nicholas C., Prados, Ferran, Jorge Cardoso, M., Tur, Carmen, De Angelis, Floriana, Cawley, Niamh, Brownlee, Wallace J, De Stefano, Nicola, Laura Stromillo, M., Battaglini, Marco, Ruggieri, Serena, Gasperini, Claudio, Filippi, Massimo, Rocca, Maria A, Rovira, Alex, Sastre-Garriga, Jaume, Geurts, Jeroen J G, Vrenken, Hugo, Wottschel, Viktor, Leurs, Cyra E, Uitdehaag, Bernard, Pirpamer, Luka, Enzinger, Christian, Ourselin, Sebastien, Gandini Wheeler-Kingshott, Claudia A, Chard, Declan, Thompson, Alan J, Barkhof, Frederik, Alexander, Daniel C, Ciccarelli, Olga, Anatomy and neurosciences, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Neurology |
| Předmět: |
Cingulate cortex
Adult Male Pathology medicine.medical_specialty Precuneus grey matter Grey matter multiple sclerosis 030218 nuclear medicine & medical imaging Cuneus 03 medical and health sciences 0302 clinical medicine Atrophy Multiple Sclerosis Relapsing-Remitting atrophy disability accumulation Medicine Humans Gray Matter 10. No inequality multiple sclerosis atrophy grey matter probabilistic modelling disability accumulation Retrospective Studies Expanded Disability Status Scale business.industry Multiple sclerosis probabilistic modelling Neurology (clinical) Brain Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease medicine.anatomical_structure Posterior cingulate Case-Control Studies multiple sclerosi Disease Progression Female business 030217 neurology & neurosurgery |
| Zdroj: | Publons Eshaghi, A, Marinescu, R V, Young, A L, Firth, N C, Prados, F, Jorge Cardoso, M, Tur, C, De Angelis, F, Cawley, N, Brownlee, W J, De Stefano, N, Laura Stromillo, M, Battaglini, M, Ruggieri, S, Gasperini, C, Filippi, M, Rocca, M A, Rovira, A, Sastre-Garriga, J, Geurts, J J G, Vrenken, H, Wottschel, V, Leurs, C E, Uitdehaag, B, Pirpamer, L, Enzinger, C, Ourselin, S, Gandini Wheeler-Kingshott, C A, Chard, D, Thompson, A J, Barkhof, F, Alexander, D C & Ciccarelli, O 2018, ' Progression of regional grey matter atrophy in multiple sclerosis ', Brain, vol. 141, no. 6, pp. 1665-1677 . https://doi.org/10.1093/brain/awy088 Brain, 141(6), 1665-1677 Web of Science |
| ISSN: | 1665-1677 0006-8950 |
| DOI: | 10.1093/brain/awy088 |
| Popis: | SummaryGrey matter atrophy is present from the earliest clinical stages of multiple sclerosis (MS), but the temporal ordering is poorly understood. We aimed to determine the sequence in which grey matter regions become atrophic in MS, and its association with disability accumulation.In this longitudinal study, we included 1,417 subjects: 253 with clinically-isolated syndrome (CIS), 708 relapsing-remitting MS (RRMS), 128 secondary-progressive MS (SPMS), 125 primary-progressive MS (PPMS), and 203 healthy controls from 7 European centres. Subjects underwent repeated MRI scanning (total number of scans 3,604); the mean follow-up for patients was 2.41yrs (SD±1.97). Disability was scored using the Expanded Disability Status Scale (EDSS). We calculated the volume of brain grey matter regions and brainstem using an unbiased within-subject template. We used an established data-driven event-based model (EBM) to determine the sequence of occurrence of atrophy and its uncertainty. We assigned each subject to a specific EBM stage, based on the number of their atrophic regions. We used nested linear mixed-effects regression models to explore the associations between the rate of increase in the EBM stages over time, disease duration and annual rate of EDSS gain.The first regions to become atrophic in CIS and relapse-onset MS patients (RRMS and SPMS) were the posterior cingulate cortex and precuneus, followed by the middle cingulate cortex, brainstem and thalamus. The sequence of atrophy in PPMS showed a similar involvement of the thalamus, cuneus, precuneus, and pallidum, followed by the brainstem and posterior cingulate cortex. The cerebellum, caudate and putamen showed early atrophy in relapse-onset MS and late atrophy in PPMS. Patients with SPMS showed the highest EBM stages (highest number of atrophic regions, all ppThis data-driven staging of atrophy progression in a large MS sample demonstrates that grey matter atrophy spreads to involve more regions over time. The sequence in which regions become atrophic is reasonably consistent across MS phenotypes. The spread of atrophy was associated with disease duration, and disability accumulation in RRMS.AbbreviationsMSmultiple sclerosisGMgrey matterFLAIRFluid Attenuated Inversion RecoveryPPMSprimary progressive multiple sclerosis; primary-progressive MS |
| Databáze: | OpenAIRE |
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