Transcranial direct current stimulation for knee osteoarthritis: a single-blind randomized sham-controlled trial
| Autor: | Sharif Najafi, Bahare Mohebi, Zahra Rezasoltani, Seyed Morteza Tabatabaee, Sirous Azizi, Afsaneh Dadarkhah |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
musculoskeletal diseases Visual analogue scale medicine.medical_treatment Pain Osteoarthritis Transcranial Direct Current Stimulation Placebo 050105 experimental psychology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Physiology (medical) medicine Humans Outpatient clinic Single-Blind Method 0501 psychology and cognitive sciences Aged Pain Measurement Crepitus Transcranial direct-current stimulation business.industry 05 social sciences General Medicine Middle Aged Osteoarthritis Knee medicine.disease Treatment Outcome Knee pain Neurology Anesthesia Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neurophysiologie Clinique. 51:329-338 |
| ISSN: | 0987-7053 |
| Popis: | To evaluate the effects of transcranial direct current stimulation on pain and other symptoms of knee osteoarthritis.We performed a single-blind randomized sham-controlled trial with two parallel arms in an outpatient clinic of physical medicine and rehabilitation at a teaching hospital. We randomized 54 patients, 30-70 years of age, with knee osteoarthritis into two groups. They had morning stiffness ≤ 30 min, knee pain ≥ 3 months, joint crepitus, and Kellgren-Lawrence grade 1 or 2 on radiographs. For the active stimulation we administered 2 mA current, 20 min for each session and for the sham group 30 s stimulation and 20 min no current. Using the 10/20 International EEG system, the anode was fixed over the contralateral primary motor cortex (C3 or C4), and the cathode was placed on the ipsilateral supraorbital region (Fp1 or Fp2), with respect to the included knee. The program was repeated once daily over 5 consecutive days. Both groups received acetaminophen. We assessed the patients before and after the interventions, and three months post-intervention. The primary outcome was knee pain on the visual analog scale, and the secondary outcome was the Knee injury and Osteoarthritis Outcome Score.There was a statistically significant reduction in the intensity of pain within sham and active groups (both p 0.001), but no significant difference between the groups (p = 0.226). Analyses of the Knee injury and Osteoarthritis Outcome Scores showed no clinically important changes.Transcranial direct current stimulation does not reduce knee pain, does not abate other symptoms, and does not restore knee function in patients with knee osteoarthritis. The pain reduction in our study could be attributed to either placebo or the acetaminophen effect. |
| Databáze: | OpenAIRE |
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