Shedding light into the black box: Advances in in vitro systems for studying implantation
| Autor: | Marlon R. Schneider, Fanny Knöspel, Zsofia Ban |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Process (engineering) Embryonic Development Cell Biology Biology Embryo Mammalian Models Biological In vitro In vitro model Endometrium 03 medical and health sciences 0302 clinical medicine Pregnancy Black box Animals Humans Compartment (development) Female Embryo Implantation Molecular Biology Neuroscience 030217 neurology & neurosurgery 030304 developmental biology Developmental Biology |
| Zdroj: | Developmental Biology. 463:1-10 |
| ISSN: | 0012-1606 |
| Popis: | Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro models are becoming useful experimental tools, as they are considerably more accessible than in vivo models, easier to manipulate, and permit the use of human cells or tissues, thus increasing the translational value of the studies. In this Review, we briefly summarize the relevant cell types and structures involved into the process of implantation, in order to outline which compartments are indispensable for creating the perfect in vitro model. We also critically address advantages and limitations of available models and assess their application potential. Moreover, we examine the chances and challenges brought by the latest approaches to recapitulate the endometrial compartment, as well as by peri-implantational embryoids. |
| Databáze: | OpenAIRE |
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