Electrochemiluminescence Aptasensor for Charged Targets through the Direct Regulation of Charge Density in Microchannels

Autor:	Yanling Huang, Fang Luo, Jian Wang, Liang Wang, Bin Qiu, Cuiying Lin, Zhenyu Lin
Rok vydání:	2021
Předmět:	Luminescent Measurements Biosensing Techniques Electrochemical Techniques Aptamers Nucleotide Ruthenium Analytical Chemistry
Zdroj:	Analytical Chemistry. 93:17127-17133
ISSN:	1520-6882 0003-2700
DOI:	10.1021/acs.analchem.1c04815
Popis:	The change of surface charge density can cause many changes in physical or chemical properties and has been applied to design many sensitive sensors. Ochratoxin A (OTA) is a negatively charged target in neutral or alkaline solutions. In this work, a microchannel-based electrochemiluminescence (ECL) aptasensor for OTA detection based on this character had been designed. The charged target directly combined with functionalization layers of the microchannels, which caused surface charge density variation and therefore resulted in the change of ECL intensity of the (1,10-phenanthroline)ruthenium(II)/tripropylamine system. The decrease of ECL intensity is linearly dependent on OTA concentration ranging from 0.5 to 4 ng mL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189824ef284e6bb2587f0a6feb7d62db https://doi.org/10.1021/acs.analchem.1c04815 Zobrazit plný text záznamu