Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam
| Autor: | Ruben O. Donis, Cam V. Nguyen, Xiu-Feng Wan, Kenjiro Inui, Amanda Balish, Stephen Lindstrom, Tung T. Nguyen, Alexander Klimov, Huong T. Ngo, Margaret McCarron, William Stembridge, Bo Shu, Hoa T. Do, Nancy J. Cox, C. Todd Davis |
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| Rok vydání: | 2009 |
| Předmět: |
Genes
Viral Sequence analysis Evolution Molecular Sequence Data Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus International trade Biology medicine.disease_cause Polymorphism Single Nucleotide Microbiology law.invention Antigen-Antibody Reactions Cloaca Phylogenetics law Virology medicine Orthomyxovirus Animals Clade Antigens Viral Polymerase chain reaction Phylogeny Poultry Diseases Genetic diversity Influenza A Virus H5N1 Subtype Highly pathogenic avian influenza virus virus diseases H5N1 Hemagglutination Inhibition Tests Influenza A virus subtype H5N1 Genetic divergence Vietnam Influenza in Birds biology.protein Geographic distribution Chickens |
| Zdroj: | Virology. 387(2) |
| ISSN: | 1096-0341 |
| Popis: | Highly pathogenic avian influenza H5N1 virus was detected in poultry seized at two ports of entry located in Lang Son Province, Vietnam. Sequence analysis of the hemagglutinin (HA) genes from five H5N1 virus isolates and ten PCR amplicons from chicken cloacal samples revealed their close phylogenetic relationship to clade 7 H5N1 HA genes. However, these HA genes exhibited extensive genetic divergence at both the nucleotide and amino acid levels in comparison to previously described clade 7 viruses; e.g., A/chicken/Shanxi/2/2006. In addition, hemagglutination inhibition tests revealed antigenic differences between these and previously isolated H5N1 viruses from Vietnam. These results indicate that viruses with clade 7 HA are evolving rapidly in poultry in Southeast Asia. |
| Databáze: | OpenAIRE |
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