Gelling hypotonic polymer solution for extended topical drug delivery to the eye
| Autor: | Matthew D. Shin, Hyounkoo Han, Ian Pitha, Byung Jin Kim, Justin Hanes, Amy Xiao, Peter J. McDonnell, Sean F. Hackett, Henry T. Hsueh, Raquel Lima e Silva, Laura M. Ensign, Youngwook Kim, Yoo Chun Kim, Ping He, Laolu Ogunnaike, Albert S. Jun, Abhijit A. Date, Charles G. Eberhart, Nicole M. Anders, Avelina Hemingway, Peter A. Campochiaro, Donald J. Zack |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Male genetic structures Contact time Polymers Swine media_common.quotation_subject Administration Topical Biomedical Engineering Medicine (miscellaneous) Bioengineering Eye Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Animals media_common Topical drug Chemistry eye diseases Computer Science Applications Posterior segment of eyeball Mice Inbred C57BL Blurring vision 030104 developmental biology Hypotonic Solutions Polymer solution Drug delivery Tonicity Nanoparticles Female sense organs Rabbits Ophthalmic Solutions Gels 030217 neurology & neurosurgery Biotechnology Biomedical engineering |
| Zdroj: | Nature biomedical engineering. 4(11) |
| ISSN: | 2157-846X |
| Popis: | Eye-drop formulations should hold as high a concentration of soluble drug in contact with ocular epithelium for as long as possible. However, eye tears and frequent blinking limit drug retention on the ocular surface, and gelling drops typically form clumps that blur vision. Here, we describe a gelling hypotonic solution containing a low concentration of a thermosensitive triblock copolymer for extended ocular drug delivery. On topical application, the hypotonic formulation forms a highly uniform and clear thin layer that conforms to the ocular surface and resists clearance from blinking, increasing the intraocular absorption of hydrophilic and hydrophobic drugs and extending the drug-ocular-epithelium contact time with respect to conventional thermosensitive gelling formulations and commercial eye drops. We also show that the conformal gel layer allows for therapeutically relevant drug delivery to the posterior segment of the eyeball in pigs. Our findings highlight the importance of formulations that conform to the ocular surface before viscosity enhancement for increased and prolonged ocular surface contact and drug absorption. |
| Databáze: | OpenAIRE |
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