Safety and effectiveness of cannabinoids to Danish patients with treatment refractory chronic pain-A retrospective observational real-world study

Autor: Horsted, Tina, Lichon Hesthaven, Karoline, Leutscher, Peter Derek Christian
Rok vydání: 2022
Předmět:
Zdroj: Horsted, T, Lichon Hesthaven, K & Leutscher, P D C 2023, ' Safety and Effectiveness of Cannabinoids to Danish Patients with Treatment Refractory Chronic Pain-A Retrospective Observational Real-world Study ', European Journal of Pain, vol. 27, no. 2, pp. 234-247 . https://doi.org/10.1002/ejp.2054
ISSN: 1532-2149
DOI: 10.1002/ejp.2054
Popis: Background: Cannabinoids are considered a therapeutic option to patients suffering from treatment refractory chronic pain (TRCP) insufficiently relieved by conventional analgesics or experiencing intolerable adverse events (AEs) from those. This study aimed to explore safety and effectiveness of oral cannabinoids among patients with TRCP. Methods: A retrospective study was conducted among Danish patients with TRCP being prescribed oral cannabinoids. Data on AEs and changes in pain intensity by numeric rating scale (NRS) before and after initiation of oral cannabinoid therapy were analysed. Results: Among 826 eligible patients ≥18 years old, 529 (64%) were included for data analysis at first follow-up (F/U1) (median 56 days from baseline) and 214 (26%) for second follow-up (F/U2) (median 126 days from F/U1). Mean age was 60 ± 15.9 years and 70% were females. AEs were in general reported mild to moderate by 42% of patients at F/U1 and 34% at F/U2. AEs were mainly related to gastrointestinal (F/U1: 17% and F/U2: 13%) and nervous system disorders (F/U1: 14% and F/U2: 11%). Reduction in NRS was significantly different at both follow-up consultations compared with baseline (
Databáze: OpenAIRE
Externí odkaz: