The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents
| Autor: | Deniz Deniz Ozturan, Erman Esnafoglu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Homocysteine Adolescent Physiology Homocysteine levels Folic Acid Deficiency Severity of Illness Index Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Folic Acid Vitamin D and neurology Medicine Humans 0501 psychology and cognitive sciences Vitamin B12 Vitamin D Child Depression (differential diagnoses) Childhood Depression Depressive Disorder business.industry 05 social sciences Vitamin B 12 Deficiency 030227 psychiatry Psychiatry and Mental health Vitamin B 12 chemistry Pediatrics Perinatology and Child Health Anxiety Female medicine.symptom business 050104 developmental & child psychology |
| Zdroj: | Child and adolescent mental healthReferences. 25(4) |
| ISSN: | 1475-357X |
| Popis: | BACKGROUND Depression is a heterogeneous disorder and is thought to develop as a result of complex interactions between genetic and environmental factors. One-carbon metabolism that includes vitamin B12, folic acid, and homocysteine has been investigated in psychiatric disorders like depression. In recent years, vitamin D has also been considered to contribute to psychiatric disorders. In this study, serum levels of folate, vitamin B12, and homocysteine related to one-carbon metabolism and vitamin D were investigated in children and adolescents with depression and to assess possible roles in depression pathogenesis. METHODS The study included 89 children and adolescents with depression (69 female, 20 male; mean age ± SD = 15.08 ± 1.46) and 43 control subjects (31 female, 12 male; mean age ± SD = 14.41 ± 2.32) without any DSM-5 diagnosis. Each subject completed a sociodemographic form, Childhood Depression Inventory, State-Trait Anxiety Inventory 1-2 and measured serum folate, vitamin B12, homocysteine, and 25-OH vitamin D levels. RESULTS There was no significant difference between the groups in terms of folate levels (p = .052). In the patient group, the vitamin B12 and vitamin D levels were clearly low (p values for both levels were |
| Databáze: | OpenAIRE |
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