Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France

Autor: Eléonore Blondiaux, Thibault Lecarpentier, Simon Riviere, Pierre-Louis Leger, Ricardo Carbajal, Solène Loschi, Romain Guedj, Anne-Sophie Romain, Yael Levy, Emmanuel Grimprel, Sébastien Héritier, Aurélie Schnuriger, Julia Guilbert, Pauline Parisot, Mathie Lorrot, Judith Faivre
Přispěvatelé: Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Gestionnaire, Hal Sorbonne Université
Rok vydání: 2020
Předmět:
Male
2019-20 coronavirus outbreak
Abdominal pain
Pediatrics
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Adolescent
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
[SDV]Life Sciences [q-bio]
Mucocutaneous Lymph Node Syndrome
Hospitals
University
03 medical and health sciences
Paediatric intensive care unit
0302 clinical medicine
030225 pediatrics
Pandemic
Medicine
Humans
030212 general & internal medicine
Pediatrics
Perinatology
and Child Health
Child
PIMS
Retrospective Studies
multisystem inflammatory syndrome
Kawasaki disease
business.industry
pandemic
COVID-19
Infant
General Medicine
University hospital
medicine.disease
Hospitals
Pediatric
Systemic Inflammatory Response Syndrome
3. Good health
[SDV] Life Sciences [q-bio]
Hospitalization
Editorial
Child
Preschool
Pediatrics
Perinatology and Child Health
Female
France
medicine.symptom
business
Zdroj: Acta Paediatrica (Oslo, Norway : 1992)
Acta Paediatrica
Acta Paediatrica, Wiley, 2021, 110 (3), pp.922-932. ⟨10.1111/apa.15667⟩
ISSN: 1651-2227
0803-5253
DOI: 10.1111/apa.15667⟩
Popis: International audience; Aim: This study determined the influence of the COVID-19 pandemic on the occurrence of multisystem inflammatory syndrome in children (MIS-C) and compared the main characteristics of MIS-C and Kawasaki disease (KD).Methods: We included patients aged up to 18 years of age who were diagnosed with MIS-C or KD in a paediatric university hospital in Paris from 1 January 2018 to 15 July 2020. Clinical, laboratory and imaging characteristics were compared, and new French COVID-19 cases were correlated with MIS-C cases in our hospital.Results: There were seven children with MIS-C, from 6 months to 12 years of age, who were all positive for the virus that causes COVID-19, and 40 virus-negative children with KD. Their respective characteristics were as follows: under 5 years of age (14.3% vs. 85.0%), paediatric intensive care unit admission (100% vs. 10.0%), abdominal pain (71.4% vs. 12.5%), myocardial dysfunction (85.7% vs. 5.0%), shock syndrome (85.7% vs. 2.5%) and mean and standard deviation C-reactive protein (339 ± 131 vs. 153 ± 87). There was a strong lagged correlation between the rise and fall in MIS-C patients and COVID-19 cases.Conclusion: The rise and fall of COVID-19 first wave mirrored the MIS-C cases. There were important differences between MIS-C and KD.
Databáze: OpenAIRE
Externí odkaz: