Literature-Based Enrichment Insights into Redox Control of Vascular Biology
| Autor: | Magbubah Essack, Julijana Stanimirovic, Christophe Van Neste, Mahmut Uludag, Esma R. Isenovic, Vladan Bajic, Arwa Bin Raies, Faroug Tifratene, Vladimir B. Bajic, Andreja Trpkovic, Adil Salhi, Arnaud Hungler |
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| Rok vydání: | 2019 |
| Předmět: |
Aging
Literature based Review Article Computational biology Disease Biology medicine.disease_cause Biochemistry Redox 03 medical and health sciences 0302 clinical medicine medicine Humans lcsh:QH573-671 Control (linguistics) 030304 developmental biology 0303 health sciences lcsh:Cytology business.industry Vascular biology Cell Biology General Medicine 3. Good health Oxidative Stress Knowledge base Reactive Oxygen Species business Oxidation-Reduction 030217 neurology & neurosurgery Function (biology) Oxidative stress |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) |
| ISSN: | 1942-0994 1942-0900 |
| DOI: | 10.1155/2019/1769437 |
| Popis: | In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic. |
| Databáze: | OpenAIRE |
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