Measurement of canine pancreatic perfusion using dynamic computed tomography: Influence of input–output vessels on deconvolution and maximum slope methods
| Autor: | Miori Kishimoto, Shujiro Yazumi, Yoh Ichi Miyake, Toshiroh Iwasaki, Tsutomu Chiba, Ki Ja Lee, Yoshihisa Tsuji, Junichiro Shimizu, Kazutaka Yamada, Nana Katabami |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Perfusion Imaging
Blood volume Perfusion scanning Sensitivity and Specificity Dogs medicine Animals Radiology Nuclear Medicine and imaging Pancreas business.industry Angiography Reproducibility of Results General Medicine Blood flow Contrast medium medicine.anatomical_structure Regional Blood Flow Splenic vein Radiographic Image Interpretation Computer-Assisted Iohexol Tomography X-Ray Computed Nuclear medicine business Algorithms Blood Flow Velocity medicine.drug Artery |
| Zdroj: | European Journal of Radiology. 77:175-181 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2009.06.016 |
| Popis: | We investigated whether the prerequisite of the maximum slope and deconvolution methods are satisfied in pancreatic perfusion CT and whether the measured parameters between these algorithms are correlated.We examined nine beagles injected with iohexol (200 mgI kg(-1)) at 5.0 ml s(-1). The abdominal aorta and splenic and celiac arteries were selected as the input arteries and the splenic vein, the output veins. For the maximum slope method, we determined the arterial contrast volume of each artery by measuring the area under the curve (AUC) and compared the peak enhancement time in the pancreas with the contrast appearance time in the splenic vein. For the deconvolution method, the artery-to-vein collection rate of contrast medium was calculated. We calculated the pancreatic tissue blood flow (TBF), tissue blood volume (TBV), and mean transit time (MTT) using both algorithms and investigated their correlation based on vessel selection.The artery AUC significantly decreased as it neared the pancreas (P0.01). In all cases, the peak time of the pancreas (11.5±1.6) was shorter than the appearance time (14.1±1.6) in the splenic vein. The splenic artery-vein combination exhibited the highest collection rate (91.1%) and was the only combination that was significantly correlated between TBF, TBV, and MTT in both algorithms.Selection of a vessel nearest to the pancreas is considered as a more appropriate prerequisite. Therefore, vessel selection is important in comparison of the semi-quantitative parameters obtained by different algorithms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect