Quality of Life Is Associated With Survival in Patients With Gastric Cancer: Results From the Randomized CRITICS Trial
| Autor: | van Amelsfoort, R. M., Walraven, I., Kieffer, J., Jansen, E. P. M., Cats, A., van Grieken, N. C. T., Meershoek-Klein Kranenbarg, E., Putter, H., van Sandick, J. W., Sikorska, K., van de Velde, C. J. H., Aaronson, N. K., Verheij, M., Boot, H., Trip, A., van Coevorden, F., Vanhoutvin, S., Swellengrebel, H. A. M., Hulshof, M. C. C. M., van Berge Henegouwen, M. I., van Laarhoven, H. W. M., Loosveld, O. J. L., ten Tije, A. J., Erdkamp, F. L. G., Warmerdam, F. A. R. M., van der Peet, D. L., Verheul, H. M. W., Portielje, J. E. A., Spillenaar Bilgen, E. J., Poleé, M. B., Geenen, M. M., Neelis, K. J., Slingerland, M., Jansen, R. L. H., van Spronsen, D. J., Tanis, B. C., van Hillegersberg, R., Koopman, M., den Boer, M. O., Creemers, G. J., van den Berg, H. P., Baars, A., Appels, M. I. E., Smit, J. M., Muller, E. W., de Boer, J., van Dijk, M. A., van der Gaast, A., Otten, J. M. M. B., Ceha, H. M. |
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| Přispěvatelé: | Radiotherapy, CCA - Cancer Treatment and Quality of Life, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Internal medicine, CCA - Cancer Treatment and quality of life, Medical oncology, Medical Oncology |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
All institutes and research themes of the Radboud University Medical Center SDG 3 - Good Health and Well-being Oncology Stomach Neoplasms Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] Surveys and Questionnaires Quality of Life Humans Prognosis Neoadjuvant Therapy |
| Zdroj: | Journal of the National Comprehensive Cancer Network, 20(3), 261-267. Cold Spring Publishing LLC van Amelsfoort, R M, Walraven, I, Kieffer, J, Jansen, E P M, Cats, A, van Grieken, N C T, Meershoek-Klein Kranenbarg, E, Putter, H, van Sandick, J W, Sikorska, K, van de Velde, C J H, Aaronson, N K, Verheij, M & CRITICS investigators 2022, ' Quality of Life Is Associated With Survival in Patients With Gastric Cancer : Results From the Randomized CRITICS Trial ', JNCCN Journal of the National Comprehensive Cancer Network, vol. 20, no. 3, pp. 261-267 . https://doi.org/10.6004/JNCCN.2021.7057 Journal of the National Comprehensive Cancer Network, 20, 261-267 JNCCN Journal of the National Comprehensive Cancer Network, 20(3), 261-267. Cold Spring Publishing LLC CRITICS investigators 2022, ' Quality of Life Is Associated With Survival in Patients With Gastric Cancer : Results From the Randomized CRITICS Trial ', JNCCN Journal of the National Comprehensive Cancer Network, vol. 20, no. 3, pp. 261-267 . https://doi.org/10.6004/JNCCN.2021.7057 Journal of the National Comprehensive Cancer Network, 20(3), 261-+. HARBORSIDE PRESS Journal of the National Comprehensive Cancer Network, 20, 3, pp. 261-267 |
| ISSN: | 1540-1405 |
| DOI: | 10.6004/JNCCN.2021.7057 |
| Popis: | Background: The evaluation of health-related quality of life (HRQoL) in clinical trials has become increasingly important because it addresses the impact of treatment from the patient’s perspective. The primary aim of this study was to investigate the effect of postoperative chemotherapy and chemoradiotherapy (CRT) after neoadjuvant chemotherapy and surgery with extended (D2) lymphadenectomy on HRQoL in the CRITICS trial. Second, we investigated the potential prognostic value of pretreatment HRQoL on event-free survival (EFS) and overall survival (OS). Patients and Methods: Patients in the CRITICS trial were asked to complete HRQoL questionnaires (EORTC Quality-of-Life Questionnaire-Core 30 and Quality-of-Life Questionnaire gastric cancer–specific module) at baseline, after preoperative chemotherapy, after surgery, after postoperative chemotherapy or CRT, and at 12 months follow-up. Patients with at least 1 evaluable questionnaire (645 of 788 randomized patients) were included in the HRQoL analyses. The predefined endpoints included dysphagia, pain, physical functioning, fatigue, and Quality-of-Life Questionnaire-Core 30 summary score. Linear mixed modeling was used to assess differences over time and at each time point. Associations of baseline HRQoL with EFS and OS were investigated using multivariate Cox proportional hazards analyses. Results: At completion of postoperative chemo(radio)therapy, the chemotherapy group had significantly better physical functioning (P=.02; Cohen’s effect size = 0.42) and less dysphagia (P=.01; Cohen’s effect size = 0.38) compared with the CRT group. At baseline, worse social functioning (hazard ratio [HR], 2.20; 95% CI, 1.36–3.55; P=.001), nausea (HR, 1.89; 95% CI, 1.39–2.56; PP=.007), and histologic subtype (diffuse vs intestinal: HR, 1.94; 95% CI, 1.42–2.67; PP=.003) were significantly associated with worse EFS and OS. Conclusions: In the CRITICS trial, the chemotherapy group had significantly better physical functioning and less dysphagia after postoperative treatment. HRQoL scales at baseline were significantly associated with EFS and OS. |
| Databáze: | OpenAIRE |
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