Formulation and physiologic factors affecting the pharmacology of carrier-mediated anticancer agents
| Autor: | William C. Zamboni, Andrew T. Lucas, Andrew J. Madden |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Tumor targeting
Antineoplastic Agents Pharmacology Toxicology Drug Delivery Systems Pharmacokinetics Neoplasms Carrier mediated Tumor Microenvironment Medicine Animals Humans Tissue Distribution health care economics and organizations Drug Carriers business.industry Physiologic Factors General Medicine Small molecule humanities Solubility Drug Design Drug delivery Liposomes Nanomedicine Nanoparticles business Exposure duration |
| Zdroj: | Expert opinion on drug metabolismtoxicology. 11(9) |
| ISSN: | 1744-7607 |
| Popis: | Major advances in carrier-mediated agents (CMAs), which include nanoparticles and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages such as increased exposure duration, greater solubility and delivery to tumor sites over their small molecule counterparts, there is substantial variability in how individual CMA formulations affect the pharmacology, pharmacokinetics and pharmacodynamics (efficacy and toxicity) of these agents.CMA formulations are complex in nature compared to their small molecule counterparts and consist of multiple components and variables that can affect the pharmacological profile. This review provides an overview of factors that affect the pharmacologic profiles observed in CMA-formulated chemotherapy, primarily in liposomal formulations, that are currently in preclinical or early clinical development.Despite the numerous advantages that CMA formulations provide, their clinical use is still in its infancy. It is critical that we understand the mechanisms and effects of CMAs in navigating biological barriers and how these factors affect their biodistribution and delivery to tumors. Future studies are warranted to better understand the complex pharmacology and interaction between CMA carriers and biological systems, such as the mononuclear phagocyte system and tumor microenvironment. |
| Databáze: | OpenAIRE |
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