Evaluation of the Cytotoxic Activity of Some Brazilian Medicinal Plants
| Autor: | Arie Fitzgerald Blank, Cláudia Pessoa, Thanany Brasil da Silva, Renata Silva-Mann, Adriana Andrade Carvalho, Péricles Barreto Alves, Jemmyson Romário de Jesus, Alan D. C. Santos, Maria Lúcia B. Pinheiro, C.S. Anjos, Manoel Odorico de Moraes, Moacir S. Andrade, Wesley Faria Gomes, Taís Santos Sampaio, Valéria Regina de Souza Moraes, Emmanoel V. Costa, Sandra Santos Ribeiro, A.M. Jesus, Ana Paula do Nascimento Prata, Paulo Cesar de Lima Nogueira, Daniel P. Bezerra |
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| Rok vydání: | 2012 |
| Předmět: |
Latex
Cell Survival Hyptis Annonaceae Pharmaceutical Science Jatropha Analytical Chemistry Bridged Bicyclo Compounds Magnoliopsida Coumarins Cell Line Tumor Clusiaceae Drug Discovery Botany Oils Volatile Humans Bicyclic Monoterpenes Pharmacology Lippia Plants Medicinal biology Traditional medicine Plant Extracts Verbenaceae Organic Chemistry Plant Components Aerial biology.organism_classification Antineoplastic Agents Phytogenic Kielmeyera Apocynaceae Complementary and alternative medicine Monoterpenes Molecular Medicine Lamiaceae Annona salzmannii Annona Brazil |
| Zdroj: | Planta Medica. 78:1601-1606 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0032-1315043 |
| Popis: | Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, β-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs. |
| Databáze: | OpenAIRE |
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