Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress
| Autor: | Govindaswamy Ilavazhagan, Anju Bansal, Kalpana Shrivastava, P.K. Banerjee, M. Sairam, Dhananjay Shukla |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment Altitude Sickness medicine.disease_cause Neuroprotection Antioxidants Rats Sprague-Dawley Superoxide dismutase Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Hypoxia Brain chemistry.chemical_classification biology Chemistry Glutathione peroxidase Brain Antimutagenic Agents Cobalt Cell Biology Glutathione Hypoxia (medical) Hypoxia-Inducible Factor 1 alpha Subunit Reactive Nitrogen Species Enzymes Rats Heme oxygenase Oxidative Stress Atmospheric Pressure Neuroprotective Agents Endocrinology Biochemistry Heme Oxygenase (Decyclizing) biology.protein Metallothionein Lipid Peroxidation medicine.symptom Reactive Oxygen Species Oxidative stress |
| Zdroj: | Neurochemistry International. 52:368-375 |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/j.neuint.2007.07.005 |
| Popis: | Hypobaric hypoxia, characteristic of high altitude is known to increase the formation of reactive oxygen and nitrogen species (RONS), and decrease effectiveness of antioxidant enzymes. RONS are involved and may even play a causative role in high altitude related ailments. Brain is highly susceptible to hypoxic stress and is involved in physiological responses that follow. Exposure of rats to hypobaric hypoxia (7619 m) resulted in increased oxidation of lipids and proteins due to increased RONS and decreased reduced to oxidized glutathione (GSH/GSSG) ratio. Further, there was a significant increase in superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) levels. Increase in heme oxygenase 1 (HO-1) and heat shock protein 70 (HSP70) was also noticed along with metallothionein (MT) II and III. Administration of cobalt appreciably attenuated the RONS generation, oxidation of lipids and proteins and maintained GSH/GSSH ratio similar to that of control cells via induction of HO-1 and MT offering efficient neuroprotection. It can be concluded that cobalt reduces hypoxia oxidative stress by maintaining higher cellular HO-1 and MT levels via hypoxia inducible factor 1alpha (HIF-1alpha) signaling mechanisms. These findings provide a basis for possible use of cobalt for prevention of hypoxia-induced oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect