2-[18F]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors

Autor:	A G, Horti, U, Scheffel, A O, Koren, H T, Ravert, W B, Mathews, J L, Musachio, P A, Finley, E D, London, R F, Dannals
Rok vydání:	1998
Předmět:	Male Fluorine Radioisotopes Mice Cancer Research Injections Intravenous Animals Azetidines Molecular Medicine Tissue Distribution Radiology Nuclear Medicine and imaging Receptors Nicotinic Binding Competitive
Zdroj:	Nuclear Medicine and Biology. 25:599-603
ISSN:	0969-8051
DOI:	10.1016/s0969-8051(98)00031-6
Popis:	The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAChR selective ligands as well as with unlabeled 2-fluoro-A-85380. A preliminary toxicology study of the 2-fluoro-A-85380 showed a relatively low biological effect. 2-[18F]Fluoro-A-85380 holds promise as a useful radiotracer for imaging of nAChRs with PET.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188d8c286bc360da8d3fb157ef77929b https://doi.org/10.1016/s0969-8051(98)00031-6 Zobrazit plný text záznamu Full Text from ScienceDirect