Nalmefene enhances LH secretion in a proportion of oligo-amenorrheic athletes
| Autor: | Adrian Turner, Karen Henley, Barry A. Turnbull, Mary Bauman, J. W. McArthur, William J. Evans, Gary S. Skrinar, Beverly A. Bullen, Jon Pehrson |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Narcotic Narcotic Antagonists Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin Placebo Endocrinology Internal medicine Naloxone Humans Medicine Ingestion Amenorrhea Progesterone Nalmefene Analysis of Variance Physical Education and Training Estradiol biology business.industry Athletes Androstenedione Dehydroepiandrosterone General Medicine Luteinizing Hormone biology.organism_classification Naltrexone Menstruation Substance Withdrawal Syndrome Oligomenorrhea Thyroxine Opioid Pituitary Gland Vagina Female business Sports medicine.drug Blood sampling |
| Zdroj: | Acta Endocrinologica. 128:325-333 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1280325 |
| Popis: | The influence upon LH secretion of doses of nalmefene, an orally effective congener of naloxone, and a placebo was compared in nine oligo-amenorrheic athletes with that in five regularly menstruating non-athletic women as a test for periodic elevations in hypothalamic opioid tone. After a 360-min control period, LH levels were followed for an additional 360 min following ingestion of the medications in random order approximately six weeks apart, 10-min blood sampling being employed throughout. The mean amplitude post-nalmefene in the athletes was significantly greater than pre- (p sd (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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