ParaSight-F test for the detection of treatment failure in multidrug resistant Plasmodium falciparum malaria
| Autor: | Msengi Ibrahim, Yupaporn Wattanagoon, Oumaporn Tasanor, A Thanavibul, Juntra Karbwang, W. Rooney, Kanda T, Kesara Na-Bangchang |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Treatment outcome Plasmodium falciparum Sensitivity and Specificity Treatment failure Uncomplicated malaria Antimalarials F-test Internal medicine parasitic diseases medicine Animals Humans Artemether Treatment Failure Malaria Falciparum biology business.industry Public Health Environmental and Occupational Health General Medicine medicine.disease biology.organism_classification Artemisinins Drug Resistance Multiple Surgery Multiple drug resistance Infectious Diseases Female Parasitology business Sesquiterpenes Malaria medicine.drug |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 90(5) |
| ISSN: | 0035-9203 |
| Popis: | The ParaSight-F test for the detection of Plasmodium falciparum was evaluated for its accuracy and usefulness in predicting treatment outcome in 75 patients (70 males, 5 females) with acute uncomplicated malaria who attended a malaria clinic in Mae Sot, Tak province, on the Thai-Myanmar border. All patients were admitted to the clinic for 28 d to exclude reinfection. The test was performed using blood samples collected into ethylenediaminetetraacetic acid from the patients on admission, and on days 1, 2, 7, and 14. The presence of microscopically detectable parasitaemia was used as the reference for sensitivity and specificity of the test. The reappearance of parasites on day 28 was used to determine the accuracy of predicting the outcome of artemether treatment on day 14. The sensitivity of the ParaSight-F test on admission, and on days 1, 2, 7, and 14, was 98.7%, 96.7%, 100%, 100% and 100%, respectively, with corresponding specificities of 50%, 24.2%, 47.1% and 72.9%. The sensitivity for predicting recrudescence by using the test on day 14 was 100%, with 97.7% specificity, and the sensitivity of predicting a sensitive response on day 14 was 97.7%, with 100% specificity. The test seems to permit more precise detection of treatment failure under 'field' conditions if used on day 14 after the start of treatment. |
| Databáze: | OpenAIRE |
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