Transient and prolonged facilitation of tone-evoked responses induced by basal forebrain stimulations in the rat auditory cortex
| Autor: | Elizabeth Hennevin, Bernard Hars, C. Maho, Jean-Marc Edeline |
|---|---|
| Přispěvatelé: | Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Atropine
Male MESH: Rats [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Acoustic Stimulation Context (language use) Auditory cortex 03 medical and health sciences MESH: Prosencephalon MESH: Atropine 0302 clinical medicine Prosencephalon Parasympathetic Nervous System Cortex (anatomy) Neuroplasticity MESH: Electroencephalography medicine Animals MESH: Animals MESH: Neuronal Plasticity Cholinergic neuron Rats Wistar 030304 developmental biology Auditory Cortex 0303 health sciences Basal forebrain Neuronal Plasticity [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior General Neuroscience MESH: Electric Stimulation [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Electroencephalography MESH: Rats Wistar Electric Stimulation MESH: Male Rats MESH: Evoked Potentials Auditory Electrophysiology medicine.anatomical_structure Acoustic Stimulation Evoked Potentials Auditory Cholinergic MESH: Parasympathetic Nervous System MESH: Auditory Cortex Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Experimental Brain Research Experimental Brain Research, Springer Verlag, 1994, 97 (3), pp.373-86. ⟨10.1007/bf00241531⟩ |
| ISSN: | 0014-4819 1432-1106 |
| DOI: | 10.1007/bf00241531⟩ |
| Popis: | International audience; We investigated the relationships between cortical arousal and cholinergic facilitation of evoked responses in the auditory cortex. The basal forebrain (BF) was stimulated unilaterally, while cluster recordings were obtained simultaneously from both auditory cortices in urethane-anesthetized rats. The global electroencephalogram (EEG; large frontoparietal derivation) and the local EEG (from the auditory cortex) were recorded. The BF was stimulated at two intensities, a lower one which did not desynchronize the EEG and a higher one which did. Twenty pairing trials were delivered, during which a tone was presented 50 ms after the end of the BF stimulation. At low intensity, the pairing procedure led to a transient increase in the ipsilateral tone-evoked responses. At high intensity, the pairing increased the ipsilateral evoked responses up to 15 min after pairing. Such effects were not observed for the contralateral recordings. Systemic atropine injection prevented the facilitations observed ipsilaterally. BF stimulations alone did not induce any increased evoked response either at low or at high intensity. These results show (1) that a tone, presented while the cortex is activated by cholinergic neurons of the BF, evokes enhanced cortical responses, and (2) that the duration of this facilitation is dependent on the stimulation intensity. These results are discussed in the context of neural mechanisms involved in general arousal and cortical plasticity. |
| Databáze: | OpenAIRE |
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