Cross-reactive antibody responses to the 2009 A/H1N1v influenza virus in the Italian population in the pre-pandemic period
| Autor: | Antonino Bella, Simona Piccirella, Silvia Declich, Maria Cristina Rota, Giulia Lapini, Caterina Rizzo, Maria Grazia Caporali, Alessia Ranghiasci, Valeria Alfonsi, Stefania Salmaso, Emanuele Montomoli |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.disease_cause Antibodies Viral Serology Influenza A Virus H1N1 Subtype Seroepidemiologic Studies Pandemic Influenza A virus Medicine Child education.field_of_study biology Geography Age Factors Middle Aged Infectious Diseases Italy Child Preschool Molecular Medicine Female Viral disease influenza Adult Adolescent Orthomyxoviridae Population Cross Reactions Hemolysis Virus Young Adult Neutralization Tests Influenza Human Seroprevalence Humans education Aged General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Infant Hemagglutination Inhibition Tests biology.organism_classification vaccination Virology Cross-Sectional Studies Immunology Antibody Formation business |
| Popis: | To assess in Italy the pre-pandemic susceptibility of the general population to the 2009 A/H1N1v influenza virus, 587 serum samples collected in 2004 were analyzed using haemagglutination-inhibition (HI), single-radial-haemolysis (SRH) and microneutralisation (MN) assays. Serum samples were stratified by age group, gender, and geographic area. Overall, using HI assay, the proportion of subjects showing antibodies cross-reacting with 2009 A/H1N1v virus at seroprotection level (>or=1:40) was estimated to be 6.7%, 12.4%, and 22.4% in individuals born between 2004 and 1949, 1948 and 1939, 1938 and 1909, respectively. With a HI antibody titre of >or=1:10, in the same birth cohort, the seroprotection levels were 13.5%, 19.2%, and 58.2%, respectively. The results suggest that the Italian population was not fully naif to the current pandemic virus and that the possible previous exposure and immune response increases with age. |
| Databáze: | OpenAIRE |
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