Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis
| Autor: | Ke Wang, Lihua Qin, Guangxia Cui, Huijie Leng, Xing Chen, Weiguang Zhang, Jianwei Wang, Jing Jia, Sai-Nan Zhu, Wenpei Bai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
Cimicifuga medicine.medical_specialty Time Factors Bone density Ovariectomy Osteoporosis lcsh:Medicine Bone and Bones Bone resorption Bone remodeling Bone Density Internal medicine medicine Animals Femur lcsh:Science Bone mineral Multidisciplinary Plant Extracts business.industry lcsh:R Estradiol valerate medicine.disease Rats Radiography Disease Models Animal Endocrinology Ovariectomized rat lcsh:Q Female Bone Remodeling business Biomarkers Research Article medicine.drug |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 12, p e82815 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0082815 |
| Popis: | This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|