Comparative evaluation of the protective effects of oral administration of auraptene and umbelliprenin against CFA-induced chronic inflammation with polyarthritis in rats
| Autor: | Zahra Gholizadeh, Armin Attaran Zadeh, Mehrdad Iranshahi, Majid Zeinali, Vahid Reza Askari, Kobra Shirani, Faezeh Vahdati Hassani, Zhila Taherzadeh |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_treatment Freund's Adjuvant Anti-Inflammatory Agents Administration Oral Inflammation RM1-950 Pharmacology Protective Agents Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Coumarins Oral administration Animals Edema Medicine Umbelliferones Rheumatoid arthritis Rats Wistar business.industry Arthritis Auraptene Interleukin-17 Chronic inflammation General Medicine medicine.disease Arthritis Experimental Rats 030104 developmental biology Cytokine chemistry 030220 oncology & carcinogenesis Prednisolone Cytokines Polyarthritis Therapeutics. Pharmacology Interleukin 17 medicine.symptom business Umbelliprenin medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111635-(2021) |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2021.111635 |
| Popis: | This study aimed to evaluate the anti-inflammatory effect of Auraptene (AUR) and Umbelliprenin (UMB) in a rat model of rheumatoid arthritis (RA) induced by using complete Freund's adjuvant (CFA).Paw swelling of adjuvant arthritis rats measured at various times after CFA injection. Over 15 days of RA induction, mediator/cytokine-mediated processes involved in managing the regulation and resolving RA's inflammation were also quantified with ELISA. Histopathological changes were also assessed under a microscope 15 days after the CFA injection.AUR at all doses and UMB administration only at a 16 mM /kg administration dose significantly reduced CFA-induced paw edema level compared to the control group. UMB (64 and 32 mM) and AUR (64, 32, and 16 mM) could reduce the PGE2 (p .05). Unlike indomethacin and prednisolone, treatment of rats with AUR (16, 32, and 64 mM/kg) and UMB (16 and 32 mM/kg) reduced the level of IL-2 (p |
| Databáze: | OpenAIRE |
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