Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications
| Autor: | Myriam Fernandez-Sendin, Angela Bella, Ignacio Melero, Alvaro Teijeira, Assunta Cirella, Leire Arrizabalaga, José Medina-Echeverz, Claudia Augusta Di Trani, Pedro Berraondo, Fernando Aranda |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Colorectal cancer Translational research Review lcsh:RC254-282 Metastasis 03 medical and health sciences Peritoneal cavity 0302 clinical medicine medicine metastasis Tumor microenvironment business.industry peritoneal microenvironment animal model Cancer peritoneal carcinomatosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health Peritoneal carcinomatosis 030104 developmental biology medicine.anatomical_structure Oncology translational research 030220 oncology & carcinogenesis Cancer research Ovarian cancer business |
| Zdroj: | Cancers, Vol 13, Iss 963, p 963 (2021) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary Peritoneal carcinomatosis mouse models as a platform to test, improve and/or predict the appropriate therapeutic interventions in patients are crucial to providing medical advances. Here, we overview reported mouse models to explore peritoneal carcinomatosis in translational biomedical research. Abstract Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents. |
| Databáze: | OpenAIRE |
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