New CeO 2 nanoparticles-based topical formulations for the skin protection against organophosphates
| Autor: | Thierry Devers, Tifenn Boutard, Denis Josse, Cécile Bignon, Frédéric Guittard, Arnaud Zenerino, Sonia Amigoni |
|---|---|
| Přispěvatelé: | Surfaces & Interfaces, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Cibles et médicaments de l'infection, de l'immunité et du cancer (IICiMed), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), IUT de Chartres, Université d'Orléans (UO) |
| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
Health Toxicology and Mutagenesis Nanoparticle Nanotechnology engineering.material Toxicology Article Topical skin protection Paraoxon Adsorption Coating lcsh:RA1190-1270 Skin equivalent health care economics and organizations lcsh:Toxicology. Poisons chemistry.chemical_classification technology industry and agriculture [CHIM.MATE]Chemical Sciences/Material chemistry Polymer Penetration (firestop) Permeation chemistry Chemical engineering Cerium dioxide Emulsion engineering Nanoparticles Thickening polymers |
| Zdroj: | Toxicology Reports Toxicology Reports, Elsevier, 2015, 2, pp.1007-1013. ⟨10.1016/j.toxrep.2015.07.003⟩ Toxicology Reports, Vol 2, Iss C, Pp 1007-1013 (2015) |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2015.07.003 |
| Popis: | International audience; To reinforce skin protection against organophosphates (OPs), the development of new topical skin protectants (TSP) has received a great interest. Nanoparticles like cerium dioxide (CeO2) known to adsorb and neutralize OPs are interesting candidates for TSP. However, NPs are difficult to disperse into formulations and they are suspected of toxicological issues. Thus we want to study: (1) the effect of the addition of CeO2 NPs in formulations for the skin protection (2) the impact of the doping of CeO2 NPs by calcium; (3) the effect of two methods of dispersion of CeO2 NPs: an O/W emulsion or a suspension of a fluorinated thickening polymer (HASE-F) grafted with these NPs. As a screening approach we used silicone membranes as a skin equivalent and Franz diffusion cells for permeation tests. The addition of purum CeO2 NPs in both formulations permits the penetration to decrease by a 3 to 4-fold factor. The O/W emulsion is the best approach to obtain a film-forming coating with a good reproducibility of the penetration results; whereas the grafting of NPs to a thickener is the best way to obtain an efficient homogenous suspension of CeO2 NPs with a decreased of toxicological impact but the coating is less film-forming which slightly impacts the reproducibility of the penetration results. |
| Databáze: | OpenAIRE |
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