MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
| Autor: | Cornelis F. M. Sier, W. van Duijn, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Alexandra M. J. Langers, F.J.G.M. Kubben, H. W. Verspaget, Daan W. Hommes, J. J. van der Reijden |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty matrix metalloproteinase Colorectal cancer Short Communication SNP Enzyme-Linked Immunosorbent Assay carcinoma Mouse model of colorectal and intestinal cancer Matrix metalloproteinase Biology Polymerase Chain Reaction Polymorphism Single Nucleotide survival Gastroenterology normal mucosa angiogenesis Internal medicine medicine Humans Prospective Studies Prospective cohort study Survival rate Aged Neoplasm Staging Retrospective Studies Mucous Membrane Cancer Mucous membrane Retrospective cohort study Prognosis medicine.disease Survival Rate medicine.anatomical_structure Matrix Metalloproteinase 9 Oncology Matrix Metalloproteinase 2 Female ELISA Colorectal Neoplasms Polymorphism Restriction Fragment Length |
| Zdroj: | British Journal of Cancer, 106(9), 1495-1498 British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2012.80 |
| Popis: | Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. Results: A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (−1306C>T) and MMP-9 (−1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. Conclusion: MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients. |
| Databáze: | OpenAIRE |
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